Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Sulfacytine Action Pathway
Escherichia coli (strain K12)
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2023-08-28
Last Updated: 2023-11-27
Sulfacytine is a short-acting antibiotic from the sulfonamide drug class. This drug class consists of synthetic bacteriostatic antibiotics with a broad spectrum against most gram-positive and many gram-negative organisms. Sulfacytine is indicated in the treatment of acute urinary tract infections. Sulfacytine inhibits the multiplication of bacteria by acting as a competitive inhibitor of dihydropteroate synthase in the folic acid metabolism cycle. This enzyme does the condensation of the pteridine with the para-aminobenzoic acid (PABA). The inhibition causes the bacteria to stop growing. This drug is administered as an oral tablet but was discontinued in 2006 (FDA).
References
Sulfacytine Pathway References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Hughes J, Roberts LC, Coppridge AJ: Sulfacytine: a new sulfonamide. Double-blind comparison with sulfisoxazole in acute uncomplicated urinary tract infections. J Urol. 1975 Dec;114(6):912-4. doi: 10.1016/s0022-5347(17)67173-8.
Pubmed: 1195474
Way KE: Double-blind comparison of sulfacytine, a new sulfonamide, with sulfisoxazole in acute uncomplicated urinary tract infections. Curr Ther Res Clin Exp. 1976 Feb;19(2):220-9.
Pubmed: 813961
Cohen AE: Sulfacytine in uncomplicated urinary tract infections. Double-blind comparison with sulfisoxazole. Urology. 1976 Mar;7(3):267-71. doi: 10.1016/0090-4295(76)90455-6.
Pubmed: 769287
Swedberg G, Fermer C, Skold O: Point mutations in the dihydropteroate synthase gene causing sulfonamide resistance. Adv Exp Med Biol. 1993;338:555-8. doi: 10.1007/978-1-4615-2960-6_113.
Pubmed: 8304179
Dallas WS, Gowen JE, Ray PH, Cox MJ, Dev IK: Cloning, sequencing, and enhanced expression of the dihydropteroate synthase gene of Escherichia coli MC4100. J Bacteriol. 1992 Sep;174(18):5961-70. doi: 10.1128/jb.174.18.5961-5970.1992.
Pubmed: 1522070
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Bognar AL, Osborne C, Shane B: Primary structure of the Escherichia coli folC gene and its folylpolyglutamate synthetase-dihydrofolate synthetase product and regulation of expression by an upstream gene. J Biol Chem. 1987 Sep 5;262(25):12337-43.
Pubmed: 3040739
Kimlova LJ, Pyne C, Keshavjee K, Huy J, Beebakhee G, Bognar AL: Mutagenesis of the folC gene encoding folylpolyglutamate synthetase-dihydrofolate synthetase in Escherichia coli. Arch Biochem Biophys. 1991 Jan;284(1):9-16. doi: 10.1016/0003-9861(91)90254-g.
Pubmed: 1989505
Nonet ML, Marvel CC, Tolan DR: The hisT-purF region of the Escherichia coli K-12 chromosome. Identification of additional genes of the hisT and purF operons. J Biol Chem. 1987 Sep 5;262(25):12209-17.
Pubmed: 3040734
Bennett CD, Rodkey JA, Sondey JM, Hirschmann R: Dihydrofolate reductase: the amino acid sequence of the enzyme from a methotrexate-resistant mutant of Escherichia coli. Biochemistry. 1978 Apr 4;17(7):1328-37. doi: 10.1021/bi00600a030.
Pubmed: 350268
Stone D, Phillips AW, Burchall JJ: The amino-acid sequence of the dihydrofolate reductase of a trimethoprim-resistant strain of Escherichia coli. Eur J Biochem. 1977 Feb;72(3):613-24. doi: 10.1111/j.1432-1033.1977.tb11284.x.
Pubmed: 320005
Smith DR, Calvo JM: Nucleotide sequence of the E coli gene coding for dihydrofolate reductase. Nucleic Acids Res. 1980 May 24;8(10):2255-74. doi: 10.1093/nar/8.10.2255.
Pubmed: 6159575
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
Downloads
Settings