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Coagulation factor VII Tissue factor Coagulation factor XIa Coagulation factor IX Prothrombin Coagulation factor VIII Coagulation factor V Coagulation factor X Coagulation factor X Prothrombin Thrombin Fibrinogen Coagulation factor XIIIa Fibrin (loose) Activated Protein C Fibrin (mesh) Fibrin (mesh) Fibrin (mesh) Fibrin degradation products Fibrin degradation products Fibrin degradation products Plasminogen Coagulation factor X Coagulation factor XIII Thrombin Protein C Thrombomodulin Coagulation factor VIII Coagulation factor IX Coagulation factor V Coagulation factor VIIa Tissue factor Calcium Calcium Calcium Calcium Calcium Calcium Calcium Calcium Calcium Tenase Complex Prothrombinase Complex Extrinsic Pathway Vascular Injury At the site of injury collagen and tissue factor are exposed to coagulation factors in the blood activating the extrinsic pathway. Extracellular Space The fibrin mesh/clot forms at the site of vascular injury, blocking the leaking blood. Blood Vessel Protein C is administered intravenously and diffuses into the bloodstream Protein C is a zymogen, meaning it is transformed into its active form after interacting with thrombomodulin into activated protein c (APC). APC inhibits coagulation factor VIII and V stopping the formation of clots
Melanosome F7 Unknown Unknown F9 Unknown F8 F5 F10 F10 Unknown Unknown Unknown F13A1 Unknown Unknown Unknown Unknown FGG Unknown Unknown FGG PLG F10 Unknown Unknown Unknown THBD F8 F9 F5 F7 Unknown
F7 F9 F8 F5 F10 F10 F13A1 FGG FGG PLG F10 THBD F8 F9 F5 F7 Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Tenase Complex Prothrombinase Complex Extrinsic Pathway Vascular Injury At the site of injury collagen and tissue factor are exposed to coagulation factors in the blood activating the extrinsic pathway. Extracellular Space The fibrin mesh/clot forms at the site of vascular injury, blocking the leaking blood. Blood Vessel Protein C is administered intravenously and diffuses into the bloodstream Protein C is a zymogen, meaning it is transformed into its active form after interacting with thrombomodulin into activated protein c (APC). APC inhibits coagulation factor VIII and V stopping the formation of clots
Melanosome F7 F9 F8 F5 F10 F10 F13A1 FGG FGG PLG F10 THBD F8 F9 F5 F7