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Epidermal growth factor receptor GRB2 SOS1 KRAS BRAF MAP2K1 PI3K complex AKT1 Pro-epidermal growth factor Lapatinib Lapatinib AKT1 mTOR Singalling Pathway Further MAPK Signalling Zinc Phosphate Lapatinib is administered as an oral tablet and delivered to the site of action via the blood. It binds to the Epidermal Growth Factor Receptor (EGFR) blocking other ligands signalling cell growth from activating the receptor. PI3K/AKT Signalling Pathway MAPK Signalling Pathway The EGFR triggers signalling cascades for many pathways such as the MAPK and PI3K/AKT pathways. AKT1 translocates to the nucleus via signalling proteins. MAPK and mTOR signalling controlls the cell's proliferation, DNA replication and overall survival and if blocked can induce apoptosis. Breast Cancer Cell Cytosol Nucleus Apoptosis Blood Vessel Breast
EGFR GRB2 SOS1 KRAS BRAF MAP2K1 PIK3R1 AKT1 EGF Nucleus Lapatinib Lapatinib AKT1 mTOR Singalling Pathway Further MAPK Signalling
EGFR GRB2 SOS1 KRAS BRAF MAP2K1 PIK3R1 AKT1 EGF Fmm Fmm AKT1 mT Si P F M S Zinc Pi Lapatinib is administered as an oral tablet and delivered to the site of action via the blood. It binds to the Epidermal Growth Factor Receptor (EGFR) blocking other ligands signalling cell growth from activating the receptor. PI3K/AKT Signalling Pathway MAPK Signalling Pathway The EGFR triggers signalling cascades for many pathways such as the MAPK and PI3K/AKT pathways. AKT1 translocates to the nucleus via signalling proteins. MAPK and mTOR signalling controlls the cell's proliferation, DNA replication and overall survival and if blocked can induce apoptosis. Breast Cancer Cell Cytosol Nucleus Apoptosis Blood Vessel Breast
EGFR GRB2 SOS1 KRAS BRAF MAP2K1 PIK3R1 AKT1 EGF Nucleus Fmm Fmm AKT1 mT Si P F M S