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Pathway Description
Histamine Muscle Contraction Pathway
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Physiological
Created: 2023-09-11
Last Updated: 2024-01-19
Histamine activates the H1 histamine receptor on bronchiole smooth muscle myocytes. This normally activates the Gq signalling cascade which activates phospholipase C which catalyzes the production of Inositol 1,4,5-trisphosphate (IP3) and Diacylglycerol (DAG). Because of the inhibition, IP3 doesn't activate the release of calcium from the sarcoplasmic reticulum, and DAG doesn't activate the release of calcium into the cytosol of the endothelial cell. This causes a low concentration of calcium in the cytosol, and it, therefore, cannot bind to calmodulin.Calcium bound calmodulin is required for the activation of myosin light chain kinase. This prevents the phosphorylation of myosin light chain 3, causing an accumulation of myosin light chain 3. This causes muscle contraction, opening up the bronchioles in the lungs, making breathing more difficult as seen in allergies
References
Histamine Muscle Contraction Pathway References
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