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Pathway Description
Fosaprepitant Drug Metabolism
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2023-09-21
Last Updated: 2024-01-21
Fosaprepitant is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Fosaprepitant passes through the liver and is then excreted from the body mainly through the kidney.
References
Fosaprepitant Drug Metabolism References
Wishart DS, Tian S, Allen D, Oler E, Peters H, Lui VW, Gautam V, Djoumbou Feunang Y, Greiner R, Metz TO; BioTransformer 3.0 – A Web Server for Accurately Predicting Metabolic Transformation Products [Submitted in Nucleic Acids Research, Webserver Issue.Apr.2022]
Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H: Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem. 1999 Jun 11;274(24):17159-63. doi: 10.1074/jbc.274.24.17159.
Pubmed: 10358072
Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. doi: 10.1074/jbc.274.52.37161.
Pubmed: 10601278
Konig J, Cui Y, Nies AT, Keppler D: A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am J Physiol Gastrointest Liver Physiol. 2000 Jan;278(1):G156-64. doi: 10.1152/ajpgi.2000.278.1.G156.
Pubmed: 10644574
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