Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
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Gq protein signaling cascade Phospholipase C Protein kinase C alpha type Histamine H1 receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Inositol 1,4,5- trisphosphate receptor type 1 Myosin light chain kinase, smooth muscle Calmodulin-1 Calmodulin-1 Histamine Inositol 1,4,5- trisphosphate Ca+ Ca+ Ca+ Phosphatidylinositol 4,5-bisphosphate Calcium Ca+ Diacylglycerol Mast Cells Release Histamine Myosin Magnesium Calcium Sarcoplasmic Reticulum Calcium cannot bind to calmodulin to activate myosin light chain kinase Myosin light chain kinase is not activated which leads to accumulation of myosin light chain 3 causing muscle relaxation There is an overall decrease in calcium levels in the cytosol caused by the inhibition of the Gq signaling cascade Cytosol Bronchiole Myocyte Clemastine antagonizes Histamine H1 receptors in smooth muscles, preventing histamine from activating the receptor Actin Actin and myosin bind bringing the filaments together causing muscle contraction Lungs Bronchioles
GNAQ PLCB1 PRKCA HRH1 CACNA1A CACNB1 CACNA2D2 ITPR1 MYLK CALM1 CALM1 Histamine Inositol 1,4,5- trisphosphate Calcium Calcium Calcium Phosphatidylinositol 4,5-bisphosphate Calcium Diacylglycerol Mast Cells Release Histamine