PathBank

Pathway Description

Pyruvate Decarboxylation to Acetyl-CoA

Bacteroides cellulosilyticus DSM 14838

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2024-10-04

Last Updated: 2025-05-31

The multi-enzyme complex catalyze three reactions that constitute a cycle, which is an essential source of acetyl-CoA. Pyruvate dehydrogenase E1 and dihydrolipoyllysine-residue acetyltransferase catalyzes pyruvic acid to acetyl-CoA and CO2. Acetyl-CoA is required for the TCA cycle. Lipoamide dehydrogenase reduces NAD+ to NADH.

References

Pyruvate Decarboxylation to Acetyl-CoA References

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0002095

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Visualize Compound Data

		Acetyl-CoA
		Carbon dioxide
		Coenzyme A
		Hydrogen Ion
		NAD
		NADH
		Pyruvic acid

Visualize Protein Data

		Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
		Dihydrolipoyl dehydrogenase
		Transketolase, thiamine diphosphate binding domain protein