PathBank

Pathway Description

D-Sorbitol Degradation II

Vibrio fluvialis PG41

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2024-11-04

Last Updated: 2025-06-01

E. coli K-12 can utilize six existing hexitols as source of carbon and energy. Hexitols can enter bacterial cell by specific phosphotransferase system, which is consisted of mannose permease IID component, mannose permease IIC component and PTS system mannose-specific EIIAB component. Sorbitol-6-phosphate will be converted to fructose 6-phosphate by sorbitol-6-phosphate dehydrogenase with cofactor NAD. Sorbitol-6-phosphate will be transformed into β-D-Fructose 6-phosphate spontaneously, which the later product will undergo glycolysis I.

References

D-Sorbitol Degradation II References

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0002036

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Visualize Compound Data

		Fructose 6-phosphate
		Hydrogen Ion
		NAD
		NADH
		Sorbitol-6-phosphate
		β-D-Fructose 6-phosphate

Visualize Protein Data

		Phosphocarrier protein HPr
		PTS system, mannose-specific IID component
		PTS system, N-acetylgalactosamine-and galactosamine-specific IIA component
		PTS system, N-acetylgalactosamine-specific IIC component
		Sorbitol-6-phosphate 2-dehydrogenase