PathBank

Pathway Description

tRNA Charging

Bacteroides sp. 4_1_36

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2024-12-17

Last Updated: 2025-07-10

This pathway is a compilation of Escherichia coli tRNA charging reactions involving amino acids transported into the cell. The aminoacyl-tRNA synthetase is an enzyme that attaches the appropriate amino acid onto its tRNA by catalyzing the esterification of a specific cognate amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA, which plays an important role in RNA translation. 20 different Aminoacyl-tRNA synthetases can make 20 different types of aa-tRNA for each amino acid according to the genetic code. This process is called "charging" or "loading" the tRNA with amino acid. Ribosome can transfer the amino acid from tRNA to a growing peptide after the tRNA is charged.

References

tRNA Charging References

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0000820

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Adenosine diphosphate
		Adenosine monophosphate
		Adenosine triphosphate
		Glycine
		Hydrogen Ion
		L-Alanine
		L-Arginine
		L-Asparagine
		L-Aspartic acid
		L-Cysteine
		L-Glutamic acid
		L-Glutamine
		L-Histidine
		L-Isoleucine
		L-Leucine
		L-Lysine
		L-Methionine
		L-Phenylalanine
		L-Proline
		L-Serine
		L-Threonine
		L-Tryptophan
		L-Tyrosine
		L-Valine
		Phosphate
		Pyrophosphate
		Water

Visualize Protein Data

		ABC transporter
		ABC transporter
		ABC transporter ATP-binding protein
		ABC transporter permease
		ABC transporter permease
		Amino acid permease
		Amino acid permease
		Arginine--tRNA ligase
		Aspartate--tRNA ligase
		BCCT family transporter
		Cysteine--tRNA ligase
		DUF4374 domain-containing protein
		DUF4988 domain-containing protein
		Glutamate--tRNA ligase
		Glutamine ABC transporter substrate-binding protein
		HAD superfamily hydrolase
		Histidine--tRNA ligase
		Iron ABC transporter permease
		Isoleucine--tRNA ligase
		Isoleucine--tRNA ligase
		Leucine--tRNA ligase
		LPS export ABC transporter ATP-binding protein
		LTA synthase family protein
		Lysine--tRNA ligase
		Methionine--tRNA ligase
		MFS transporter
		Na(+)/H(+) antiporter NhaA
		Phenylalanine--tRNA ligase alpha subunit
		Phenylalanine--tRNA ligase beta subunit
		Phosphate transport system permease protein
		Phosphate transport system permease protein
		Phosphate transport system permease protein PstA
		Proline--tRNA ligase
		Serine acetyltransferase
		Serine--tRNA ligase
		Threonyl and Alanyl tRNA synthetase second additional domain-containing protein
		Transglycosylase SLT domain-containing protein
		Tryptophan--tRNA ligase
		Tyrosine--tRNA ligase
		Unknown