PathBank

Pathway Description

tRNA Charging

Burkholderia cepacia GG4

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2024-12-17

Last Updated: 2025-08-09

This pathway is a compilation of Escherichia coli tRNA charging reactions involving amino acids transported into the cell. The aminoacyl-tRNA synthetase is an enzyme that attaches the appropriate amino acid onto its tRNA by catalyzing the esterification of a specific cognate amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA, which plays an important role in RNA translation. 20 different Aminoacyl-tRNA synthetases can make 20 different types of aa-tRNA for each amino acid according to the genetic code. This process is called "charging" or "loading" the tRNA with amino acid. Ribosome can transfer the amino acid from tRNA to a growing peptide after the tRNA is charged.

References

tRNA Charging References

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0000820

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Adenosine diphosphate
		Adenosine monophosphate
		Adenosine triphosphate
		Glycine
		Hydrogen Ion
		L-Alanine
		L-Arginine
		L-Asparagine
		L-Aspartic acid
		L-Cysteine
		L-Glutamic acid
		L-Glutamine
		L-Histidine
		L-Isoleucine
		L-Leucine
		L-Lysine
		L-Methionine
		L-Phenylalanine
		L-Proline
		L-Serine
		L-Threonine
		L-Tryptophan
		L-Tyrosine
		L-Valine
		Phosphate
		Pyrophosphate
		Water

Visualize Protein Data

		ABC transporter
		ABC transporter related protein
		Amino acid ABC transporter permease
		Amino acid ABC transporter solute binding protein
		Amino acid permease
		Amino acid permease family protein
		Aspartate--tRNA(Asp/Asn) ligase
		Bacteriocin import membrane protein
		Binding-protein-dependent transport system inner membrane protein
		Branched chain amino acid ABC transporter ATPase
		Cationic amino acid ABC transporter periplasmic binding protein
		Cationic amino acid ABC transporter, periplasmic binding protein
		Cysteine--tRNA ligase
		DUF3857 domain-containing protein
		Extracellular solute-binding protein
		Glutamate--tRNA ligase
		Glutamine ABC transporter ATP-binding protein
		Glutamine ABC transporter periplasmic protein
		Glutamine ABC transporter permease
		Glycine betaine ABC transporter substrate-binding protein
		Glycine--tRNA ligase alpha subunit
		Glycine-betaine ABC transporter permease
		Histidine ABC transporter ATP-binding protein
		Histidine/lysine/arginine/ornithine transport system permease protein HisM
		Inner-membrane translocator
		Isoleucine--tRNA ligase
		Leucine/isoleucine/valine transporter permease subunit
		Lipoprotein
		Lysine--tRNA ligase
		Lysine/arginine/ornithine ABC transporter periplasmic ligand-binding protein
		Phenylalanine--tRNA ligase alpha subunit
		Polar amino acid ABC transporter inner membrane subunit
		Polar amino acid ABC transporter inner membrane subunit
		Polar amino acid transporter ATP-binding protein
		Protein HflC
		Quaternary amine transport ATP-binding protein
		Threonine--tRNA ligase
		Threonyl/alanyl tRNA synthetase SAD
		Tryptophan--tRNA ligase
		Tyrosine--tRNA ligase
		Unknown
		Valine--tRNA ligase