PathBank

Pathway Description

tRNA Charging

Serratia marcescens subsp. marcescens Db11

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2024-12-18

Last Updated: 2025-07-10

This pathway is a compilation of Escherichia coli tRNA charging reactions involving amino acids transported into the cell. The aminoacyl-tRNA synthetase is an enzyme that attaches the appropriate amino acid onto its tRNA by catalyzing the esterification of a specific cognate amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA, which plays an important role in RNA translation. 20 different Aminoacyl-tRNA synthetases can make 20 different types of aa-tRNA for each amino acid according to the genetic code. This process is called "charging" or "loading" the tRNA with amino acid. Ribosome can transfer the amino acid from tRNA to a growing peptide after the tRNA is charged.

References

tRNA Charging References

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0000820

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Adenosine diphosphate
		Adenosine monophosphate
		Adenosine triphosphate
		Glycine
		Hydrogen Ion
		L-Alanine
		L-Arginine
		L-Asparagine
		L-Aspartic acid
		L-Cysteine
		L-Glutamic acid
		L-Glutamine
		L-Histidine
		L-Isoleucine
		L-Leucine
		L-Lysine
		L-Methionine
		L-Phenylalanine
		L-Proline
		L-Serine
		L-Threonine
		L-Tryptophan
		L-Tyrosine
		L-Valine
		Phosphate
		Pyrophosphate
		Water

Visualize Protein Data

		ABC transporter, ATP-binding protein
		ABC transporter, substrate-binding protein
		ABC transporter, substrate-binding protein
		Arginine ABC transporter permease protein ArtM
		Arginine transport ATP-binding protein ArtP
		Arginine transporter subunit
		Arginine transporter subunit
		Beta-glucoside-specific PTS system, EIIABC components
		Cell division protein ZipA
		Chaperone
		Citrate lyase alpha chain
		D-methionine transport system permease protein MetI
		D-serine/D-alanine/glycine permease
		Elongation factor P--(R)-beta-lysine ligase
		Glutamate and aspartate transporter subunit
		Glutamate and aspartate transporter subunit
		Glutamate and aspartate transporter subunit
		Glutamate--tRNA ligase
		Glutamine transporter subunit
		Glutamine transporter subunit
		Glutamine transporter subunit
		Glutamyl-Q tRNA(Asp) synthetase
		glycerophosphodiester phosphodiesterase
		Glycine betaine/carnitine/choline ABCtransporter, permease protein
		High-affinity branched-chain amino acid transport ATP-binding protein
		High-affinity branched-chain amino acid transport ATP-binding protein LivG
		Histidine ABC transporter, ATP-binding protein
		Histidine ABC transporter, permease protein
		Histidine ABC transporter, substrate-binding protein
		Histidine/lysine/arginine/ornithine transport system permease protein HisM
		Isoleucine--tRNA ligase
		Leucine--tRNA ligase
		Leucine/isoleucine/valine transporter subunit
		Leucine/isoleucine/valine transporter subunit
		Lipoprotein
		Lysine--tRNA ligase
		Methionine--tRNA ligase
		Nitrogen assimilation LysR-family transcriptional regulator
		Predicted cryptic proline transporter
		Predicted serine transporter
		Proline--tRNA ligase
		Quaternary amine transport ATP-binding protein
		serralysin
		Threonine--tRNA ligase
		Threonyl/alanyl tRNA synthetase SAD domain-containing protein
		Tryptophan--tRNA ligase
		Unknown
		Valine--tRNA ligase