PathBank

Pathway Description

tRNA Charging

Subdoligranulum variabile DSM 15176

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2024-12-18

Last Updated: 2025-06-03

This pathway is a compilation of Escherichia coli tRNA charging reactions involving amino acids transported into the cell. The aminoacyl-tRNA synthetase is an enzyme that attaches the appropriate amino acid onto its tRNA by catalyzing the esterification of a specific cognate amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA, which plays an important role in RNA translation. 20 different Aminoacyl-tRNA synthetases can make 20 different types of aa-tRNA for each amino acid according to the genetic code. This process is called "charging" or "loading" the tRNA with amino acid. Ribosome can transfer the amino acid from tRNA to a growing peptide after the tRNA is charged.

References

tRNA Charging References

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0000820

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Adenosine diphosphate
		Adenosine monophosphate
		Adenosine triphosphate
		Glycine
		Hydrogen Ion
		L-Alanine
		L-Arginine
		L-Asparagine
		L-Aspartic acid
		L-Cysteine
		L-Glutamic acid
		L-Glutamine
		L-Histidine
		L-Isoleucine
		L-Leucine
		L-Lysine
		L-Methionine
		L-Phenylalanine
		L-Proline
		L-Serine
		L-Threonine
		L-Tryptophan
		L-Tyrosine
		L-Valine
		Phosphate
		Pyrophosphate
		Water

Visualize Protein Data

		ABC transporter, ATP-binding protein
		ABC transporter, ATP-binding protein
		ABC transporter, ATP-binding protein
		ABC transporter, ATP-binding protein
		ABC transporter, permease protein
		ABC transporter, permease protein
		ABC transporter, permease protein
		ABC transporter, substrate-binding protein, family 3
		ABC transporter, substrate-binding protein, family 3
		ABC transporter, substrate-binding protein, family 3
		Amino acid carrier protein
		Arabinogalactan endo-beta-1,4-galactanase
		Arginine--tRNA ligase
		Asparagine--tRNA ligase
		Aspartate--tRNA ligase
		Branched-chain amino acid ABC transporter, permease protein
		Branched-chain amino acid ABC transporter, permease protein
		Carbon starvation protein CstA
		Cysteine--tRNA ligase
		Glutamate--tRNA ligase
		Glycosyltransferase family 6
		Histidine--tRNA ligase
		Isoleucine--tRNA ligase
		Lipoprotein
		Methionine--tRNA ligase
		Phenylalanine--tRNA ligase alpha subunit
		Phenylalanine--tRNA ligase beta subunit
		Receptor family ligand-binding protein
		Serine--tRNA ligase
		Threonine/alanine tRNA ligase second additional domain protein
		Tryptophan--tRNA ligase
		Tyrosine--tRNA ligase
		Uncharacterized protein
		Unknown
		Valine--tRNA ligase
		Zinc-ribbon domain-containing protein