PathBank

Pathway Description

tRNA Charging

Halococcus morrhuae DSM 1307

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2024-12-18

Last Updated: 2025-08-09

This pathway is a compilation of Escherichia coli tRNA charging reactions involving amino acids transported into the cell. The aminoacyl-tRNA synthetase is an enzyme that attaches the appropriate amino acid onto its tRNA by catalyzing the esterification of a specific cognate amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA, which plays an important role in RNA translation. 20 different Aminoacyl-tRNA synthetases can make 20 different types of aa-tRNA for each amino acid according to the genetic code. This process is called "charging" or "loading" the tRNA with amino acid. Ribosome can transfer the amino acid from tRNA to a growing peptide after the tRNA is charged.

References

tRNA Charging References

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0000820

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Adenosine diphosphate
		Adenosine monophosphate
		Adenosine triphosphate
		Glycine
		Hydrogen Ion
		L-Alanine
		L-Arginine
		L-Asparagine
		L-Aspartic acid
		L-Cysteine
		L-Glutamic acid
		L-Glutamine
		L-Histidine
		L-Isoleucine
		L-Leucine
		L-Lysine
		L-Methionine
		L-Phenylalanine
		L-Proline
		L-Serine
		L-Threonine
		L-Tryptophan
		L-Tyrosine
		L-Valine
		Phosphate
		Pyrophosphate
		Water

Visualize Protein Data

		ABC transporter
		ABC transporter integral membrane protein
		Alanine--tRNA ligase
		Amino acid ABC transporter amino acid-binding protein
		Amino acid permease
		Arginine--tRNA ligase
		Aspartate--tRNA(Asp/Asn) ligase
		ATPase AAA
		Binding-protein-dependent transport systems inner membrane component
		Cysteine--tRNA ligase
		Glutamate--tRNA ligase
		Glutamine ABC transporter ATP-binding protein
		Histidine--tRNA ligase
		Isoleucine--tRNA ligase
		Phenylalanine--tRNA ligase alpha subunit
		Phenylalanine--tRNA ligase beta subunit
		Polar amino acid ABC transporter permease
		Proline--tRNA ligase
		Protein N-acetyltransferase-like protein
		Putative branched-chain amino acids ABC transporter permease
		S-adenosylmethionine-dependent methyltransferase 1
		Serine--tRNA ligase
		Transporter
		Tryptophan--tRNA ligase
		Unknown
		Valine--tRNA ligase