PathBank

Pathway Description

Glycine Biosynthesis

Escherichia coli (strain K12 / MC4100 / BW2952)

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2024-12-18

Last Updated: 2025-08-09

Glycine biosynthesis is dependent on L-serine. L-serine is enters the cell through transporters (serine / threonine:H+ symporter TdcC, serine/threonine: Na symporter , serine:H+ symporter SdaC) and then proceeds through reversible reaction with a tetrahydrofolic acid through a serine hydroxymethyltransferase enzyme in order to produce glycine, 5,10-methylene tetrahydrofolate and water. 5,10-methylene tetrahydrofolate is a major source of one-carbon units used in other metabolic pathways.

References

Glycine Biosynthesis References

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0000828

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		5,10-Methylene-THF
		Glycine
		Hydrogen Ion
		L-Serine
		Sodium
		Tetrahydrofolic acid
		Water

Visualize Protein Data

		2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
		C4-dicarboxylate transport protein
		Glycine dehydrogenase (decarboxylating)
		Threonine/serine transporter TdcC