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Pathway Description
Phenylalanine Biosynthesis
Escherichia coli str. K-12 substr. DH10B
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2024-12-23
Last Updated: 2025-07-13
The phenylalaline biosynthesis pathways is connected with the chorismate biosynthesis pathway. Chorismate biosynthesis produce the chorismate, which further be converted to prephenate by P-protein. Combined with cofactor, H+, prephenate has been further converted to phenylpyruvic acid by P-protein with generated water and carbon dioxide. Phenylalanine transaminase catalyzes phenylpyruvic acid to phenylalaline, and also convert glutamic acid to oxoglutaric acid. Phenylalaline will be further used in phenylalaline metabolism.
References
Phenylalanine Biosynthesis References
Gavini N, Davidson BE: pheAo mutants of Escherichia coli have a defective pheA attenuator. J Biol Chem. 1990 Dec 15;265(35):21532-5.
Pubmed: 2254312
Hudson GS, Davidson BE: Nucleotide sequence and transcription of the phenylalanine and tyrosine operons of Escherichia coli K12. J Mol Biol. 1984 Dec 25;180(4):1023-51. doi: 10.1016/0022-2836(84)90269-9.
Pubmed: 6396419
Yamamoto Y, Aiba H, Baba T, Hayashi K, Inada T, Isono K, Itoh T, Kimura S, Kitagawa M, Makino K, Miki T, Mitsuhashi N, Mizobuchi K, Mori H, Nakade S, Nakamura Y, Nashimoto H, Oshima T, Oyama S, Saito N, Sampei G, Satoh Y, Sivasundaram S, Tagami H, Horiuchi T, et al.: Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features. DNA Res. 1997 Apr 28;4(2):91-113. doi: 10.1093/dnares/4.2.91.
Pubmed: 9205837
Kuramitsu S, Ogawa T, Ogawa H, Kagamiyama H: Branched-chain amino acid aminotransferase of Escherichia coli: nucleotide sequence of the ilvE gene and the deduced amino acid sequence. J Biochem. 1985 Apr;97(4):993-9. doi: 10.1093/oxfordjournals.jbchem.a135176.
Pubmed: 3897211
Lawther RP, Nichols B, Zurawski G, Hatfield GW: The nucleotide sequence preceding and including the beginning of the ilvE gene of the ilvGEDA operon of Escherichia coli K12. Nucleic Acids Res. 1979 Dec 20;7(8):2289-301. doi: 10.1093/nar/7.8.2289.
Pubmed: 392469
Lawther RP, Wek RC, Lopes JM, Pereira R, Taillon BE, Hatfield GW: The complete nucleotide sequence of the ilvGMEDA operon of Escherichia coli K-12. Nucleic Acids Res. 1987 Mar 11;15(5):2137-55. doi: 10.1093/nar/15.5.2137.
Pubmed: 3550695
Kuramitsu S, Okuno S, Ogawa T, Ogawa H, Kagamiyama H: Aspartate aminotransferase of Escherichia coli: nucleotide sequence of the aspC gene. J Biochem. 1985 Apr;97(4):1259-62. doi: 10.1093/oxfordjournals.jbchem.a135173.
Pubmed: 3897210
Fotheringham IG, Dacey SA, Taylor PP, Smith TJ, Hunter MG, Finlay ME, Primrose SB, Parker DM, Edwards RM: The cloning and sequence analysis of the aspC and tyrB genes from Escherichia coli K12. Comparison of the primary structures of the aspartate aminotransferase and aromatic aminotransferase of E. coli with those of the pig aspartate aminotransferase isoenzymes. Biochem J. 1986 Mar 15;234(3):593-604. doi: 10.1042/bj2340593.
Pubmed: 3521591
Kondo K, Wakabayashi S, Yagi T, Kagamiyama H: The complete amino acid sequence of aspartate aminotransferase from Escherichia coli: sequence comparison with pig isoenzymes. Biochem Biophys Res Commun. 1984 Jul 18;122(1):62-7. doi: 10.1016/0006-291x(84)90439-x.
Pubmed: 6378205
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000827
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