PathBank

Pathway Description

Secondary Metabolites: Shikimate Pathway

Bacteroides clarus YIT 12056

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2025-01-22

Last Updated: 2025-06-11

The biosynthesis of shikimate starts with D-Erythrose-4-phosphate getting transformed into 3-deoxy-D-arabino-heptulosonate-7-phosphate through a phospho-2-dehydro-3-deoxyheptonate aldolase. This is followed by a 3-dehydroquinate synthase converting the 3-deoxy-D-arabino-heptulosonate-7-phosphate into a 3-dehydroquinate which in turn is conveted to 3-dehydroshikimate through a 3-dehydroquinate dehydratase. A this point 3-dehydroshikimate can be turned into Shikimic acid through 2 different reactions involving an NADPH driven Quinate/shikimate dehydrogenase or a NADPH driven shikimate dehydrogenase 2. Shikimate can also be transported through a shikimate:H+ symporter.

References

Secondary Metabolites: Shikimate Pathway References

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0001001

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		3-Dehydroquinate
		3-dehydroshikimate
		3-deoxy-D-arabino-heptulosonate-7-phosphate
		D-Erythrose 4-phosphate
		Hydrogen Ion
		NADP
		NADPH
		Phosphate
		Phosphoenolpyruvic acid
		Shikimic acid
		Water

Visualize Protein Data

		3-dehydroquinate synthase
		asparaginase
		Phage tail component protein
		Putative 3-deoxy-7-phosphoheptulonate synthase
		Putative shikimate dehydrogenase
		Transporter, major facilitator family protein