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Pathway Description
Quorum sensing: lsrR lsrK
Escherichia coli K-12
Category:
Metabolite Pathway
Sub-Category:
Signaling
Created: 2025-01-23
Last Updated: 2025-06-11
The regulation of the lsrRK operon. The operon is inhibited by lsrR (Transcriptional regulator) and activated by high concentrations of phospho-AI-2. LsrR binds to the promoter inhibiting crp from binding and transcribing. When phospho-AI-2 is in high concentration, it binds to lsrR changing its shaping. Therefore preventing it from binding to the promoter, allowing crp to bind and transcribe the operon. Phospho-AI-2 comes from the phosphorylation of AI-2 (autoinducer 2) by lsrK (Autoinducer-2 kinase). AI-2 is transported from outside the cell by the lsrABCD transporter. There are two products from this operon: lsrR and lsrK.
References
Quorum sensing: lsrR lsrK References
Wang H, Shang F, Shen J, Xu J, Chen X, Ni J, Yu L, Xue T: LsrR, the effector of AI-2 quorum sensing, is vital for the H(2)O(2) stress response in mammary pathogenic Escherichia coli. Vet Res. 2021 Oct 2;52(1):127. doi: 10.1186/s13567-021-00998-8.
Pubmed: 34600565
Xue T, Zhao L, Sun H, Zhou X, Sun B: LsrR-binding site recognition and regulatory characteristics in Escherichia coli AI-2 quorum sensing. Cell Res. 2009 Nov;19(11):1258-68. doi: 10.1038/cr.2009.91. Epub 2009 Jul 28.
Pubmed: 19636340
Li J, Attila C, Wang L, Wood TK, Valdes JJ, Bentley WE: Quorum sensing in Escherichia coli is signaled by AI-2/LsrR: effects on small RNA and biofilm architecture. J Bacteriol. 2007 Aug;189(16):6011-20. doi: 10.1128/JB.00014-07. Epub 2007 Jun 8.
Pubmed: 17557827
Meng F, Lyu Y, Zhao H, Lyu F, Bie X, Lu Y, Zhao M, Chen Y, Lu Z: LsrR-like protein responds to stress tolerance by regulating polysaccharide biosynthesis in Lactiplantibacillus plantarum. Int J Biol Macromol. 2023 Jan 15;225:1193-1203. doi: 10.1016/j.ijbiomac.2022.11.180. Epub 2022 Nov 25.
Pubmed: 36436601
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Pubmed: 9097039
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. doi: 10.1038/msb4100049. Epub 2006 Feb 21.
Pubmed: 16738553
Xavier KB, Bassler BL: Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli. J Bacteriol. 2005 Jan;187(1):238-48. doi: 10.1128/JB.187.1.238-248.2005.
Pubmed: 15601708
Cossart P, Gicquel-Sanzey B: Cloning and sequence of the crp gene of Escherichia coli K 12. Nucleic Acids Res. 1982 Feb 25;10(4):1363-78. doi: 10.1093/nar/10.4.1363.
Pubmed: 6280141
Aiba H, Fujimoto S, Ozaki N: Molecular cloning and nucleotide sequencing of the gene for E. coli cAMP receptor protein. Nucleic Acids Res. 1982 Feb 25;10(4):1345-61. doi: 10.1093/nar/10.4.1345.
Pubmed: 6280140
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