PathBank

Pathway Description

Thiosulfate Disproportionation III

Escherichia coli (strain K12)

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2025-02-03

Last Updated: 2025-06-16

Thiosulfate sulfurtransferase (also known as rhodanese) can facilitate the transfer of a sulfur atom from sulfur donors to nucleophilic sulfur acceptors, and it has been found in many major phyla (prokaryotic and eukaryotic). The role of thiosulfate sulfurtransferase might be the detoxification of cyanide in both bacteria and mammals, or it might also involve in formation of prosthetic groups in iron-sulfur proteins. In this pathway, thiosulfate and hydrogen cyanide have been catalyzed by thiosulfate sulfurtransferase to form thiocyanate and sulfite. Sulfite is used in later sulfur metabolism.

References

Thiosulfate Disproportionation III References

Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.

Pubmed: 9278503

Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. doi: 10.1038/msb4100049. Epub 2006 Feb 21.

Pubmed: 16738553

Zhang A, Belfort M: Nucleotide sequence of a newly-identified Escherichia coli gene, stpA, encoding an H-NS-like protein. Nucleic Acids Res. 1992 Dec 25;20(24):6735. doi: 10.1093/nar/20.24.6735.

Pubmed: 1480493

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0002072

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Adenosine diphosphate
		Adenosine triphosphate
		Hydrogen cyanide
		Hydrogen Ion
		Phosphate
		Sulfite
		Thiocyanate
		Thiosulfate
		Water

Visualize Protein Data

		Fe(3+) ions import ATP-binding protein FbpC
		Inner membrane protein YgaP
		Sulfate transport system permease protein CysT
		Sulfate transport system permease protein CysW
		Thiosulfate sulfurtransferase GlpE
		Thiosulfate sulfurtransferase PspE
		Thiosulfate sulfurtransferase YnjE
		Thiosulfate-binding protein