Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Aminopropylcadaverine Biosynthesis
Escherichia coli 042
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2025-02-09
Last Updated: 2025-06-17
Aminopropylcadaverine, a polyamine, is the final product of aminopropylcadaverine biosynthesis pathway. Polyamines are involved in protein synthesis, DNA and RNA related processes, as well as the facilitation of cell stress resistance and membrane integrity; therefore polyamines are essential for cell growth. In this pathway, L-lysine is produced by lysine biosynthesis, then lysine decarboxylase will convert L-lysine into cadaverine. In the final step, spermidine synthase will catalyze cadaverine and decarboxy-SAM to aminopropylcadaverine as well as 5'-Methylthioadenosine.
References
Aminopropylcadaverine Biosynthesis References
Meng SY, Bennett GN: Nucleotide sequence of the Escherichia coli cad operon: a system for neutralization of low extracellular pH. J Bacteriol. 1992 Apr;174(8):2659-69. doi: 10.1128/jb.174.8.2659-2669.1992.
Pubmed: 1556085
Burland V, Plunkett G 3rd, Sofia HJ, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res. 1995 Jun 25;23(12):2105-19. doi: 10.1093/nar/23.12.2105.
Pubmed: 7610040
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Kikuchi Y, Kojima H, Tanaka T, Takatsuka Y, Kamio Y: Characterization of a second lysine decarboxylase isolated from Escherichia coli. J Bacteriol. 1997 Jul;179(14):4486-92. doi: 10.1128/jb.179.14.4486-4492.1997.
Pubmed: 9226257
Yamamoto Y, Miwa Y, Miyoshi K, Furuyama J, Ohmori H: The Escherichia coli ldcC gene encodes another lysine decarboxylase, probably a constitutive enzyme. Genes Genet Syst. 1997 Jun;72(3):167-72.
Pubmed: 9339543
Tabor CW, Tabor H: The speEspeD operon of Escherichia coli. Formation and processing of a proenzyme form of S-adenosylmethionine decarboxylase. J Biol Chem. 1987 Nov 25;262(33):16037-40.
Pubmed: 3316212
Xie QW, Tabor CW, Tabor H: Spermidine biosynthesis in Escherichia coli: promoter and termination regions of the speED operon. J Bacteriol. 1989 Aug;171(8):4457-65. doi: 10.1128/jb.171.8.4457-4465.1989.
Pubmed: 2666401
Tabor CW, Tabor H, Xie QW: Spermidine synthase of Escherichia coli: localization of the speE gene. Proc Natl Acad Sci U S A. 1986 Aug;83(16):6040-4. doi: 10.1073/pnas.83.16.6040.
Pubmed: 3526348
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0002053
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
Downloads
Settings