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Pathway Description
Salvage Pathways of Pyrimidine Deoxyribonucleotides
Escherichia coli S88
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2025-02-18
Last Updated: 2025-06-19
The pathway begins with the introduction of deoxycytidine into the cytosol, either through a nupG symporter or a nupC symporter. Once inside it is deaminated when reacting with a water molecule, a hydrogen ion and a deoxycytidine deaminase resulting in the release of an ammonium and a deoxyuridine. Deoxyuridine can also be imported through a nupG symporter or a nupC symporter.
Deoxyuridine can react with an ATP through a deoxyuridine kinase resulting in the release of a ADP , a hydrogen ion and a dUMP.
Deoxyuridine can also react with a phosphate through a uracil phosphorylase resulting in the release of a uracil and a deoxy-alpha-D-ribose 1-phosphate. This compound in turn reacts with a thymine through a thymidine phosphorylase resulting in the release of a phosphate and a thymidine. Thymidine in turn reacts with an ATP through a thymidine kinase resulting in a release of an ADP, a hydrogen ion and a dTMP
References
Salvage Pathways of Pyrimidine Deoxyribonucleotides References
Bockamp EO, Blasco R, Vinuela E: Escherichia coli thymidine kinase: nucleotide sequence of the gene and relationships to other thymidine kinases. Gene. 1991 May 15;101(1):9-14. doi: 10.1016/0378-1119(91)90218-z.
Pubmed: 2060797
Black ME, Hruby DE: Nucleotide sequence of the Escherichia coli thymidine kinase gene provides evidence for conservation of functional domains and quaternary structure. Mol Microbiol. 1991 Feb;5(2):373-9. doi: 10.1111/j.1365-2958.1991.tb02119.x.
Pubmed: 2041474
Danchin A, Krin E: Filling the gap between hns and adhE in Escherichia coli K12. Microbiology. 1995 Apr;141 ( Pt 4):959-60. doi: 10.1099/13500872-141-4-959.
Pubmed: 7773397
Burland V, Plunkett G 3rd, Sofia HJ, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res. 1995 Jun 25;23(12):2105-19. doi: 10.1093/nar/23.12.2105.
Pubmed: 7610040
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. doi: 10.1038/msb4100049. Epub 2006 Feb 21.
Pubmed: 16738553
Valentin-Hansen P, Holst B, Josephsen J, Hammer K, Albrechtsen B: CRP/cAMP- and CytR-regulated promoters in Escherichia coli K12: the cdd promoter. Mol Microbiol. 1989 Oct;3(10):1385-90. doi: 10.1111/j.1365-2958.1989.tb00120.x.
Pubmed: 2575702
Yang C, Carlow D, Wolfenden R, Short SA: Cloning and nucleotide sequence of the Escherichia coli cytidine deaminase (ccd) gene. Biochemistry. 1992 May 5;31(17):4168-74. doi: 10.1021/bi00132a003.
Pubmed: 1567863
Craig JE, Zhang Y, Gallagher MP: Cloning of the nupC gene of Escherichia coli encoding a nucleoside transport system, and identification of an adjacent insertion element, IS 186. Mol Microbiol. 1994 Mar;11(6):1159-68. doi: 10.1111/j.1365-2958.1994.tb00392.x.
Pubmed: 8022285
Yamamoto Y, Aiba H, Baba T, Hayashi K, Inada T, Isono K, Itoh T, Kimura S, Kitagawa M, Makino K, Miki T, Mitsuhashi N, Mizobuchi K, Mori H, Nakade S, Nakamura Y, Nashimoto H, Oshima T, Oyama S, Saito N, Sampei G, Satoh Y, Sivasundaram S, Tagami H, Horiuchi T, et al.: Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features. DNA Res. 1997 Apr 28;4(2):91-113. doi: 10.1093/dnares/4.2.91.
Pubmed: 9205837
Westh Hansen SE, Jensen N, Munch-Petersen A: Studies on the sequence and structure of the Escherichia coli K-12 nupG gene, encoding a nucleoside-transport system. Eur J Biochem. 1987 Oct 15;168(2):385-91. doi: 10.1111/j.1432-1033.1987.tb13431.x.
Pubmed: 3311747
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0002073
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