Vitamin B6 metabolism in bacteria involves the biosynthesis and utilization of various forms of Vitamin B6, primarily pyridoxal 5'-phosphate (PLP), the active form of the vitamin. Bacteria can synthesize Vitamin B6 through two main pathways: the de novo DXP-independent pathway (pyridoxal phosphate biosynthesis I) and the DXP-dependent pathway. In the de novo pathway, key enzymes like Pdx1 and Pdx2 convert intermediates into pyridoxine 5'-phosphate (PNP), which is then oxidized to PLP by the enzyme pyridoxine phosphate oxidase (PdxH). PLP acts as a cofactor for various enzymes involved in amino acid metabolism, including transaminases, decarboxylases, and racemases.Bacteria rely on PLP for critical cellular processes, including amino acid metabolism, stress response, and protection against oxidative damage.

Vitamin B6 Metabolism References