Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Arginine degradation; Arginine biosynthesis: artP, artI, artQ, artM
Escherichia coli K-12
Category:
Metabolite Pathway
Sub-Category:
Signaling
Created: 2025-03-04
Last Updated: 2025-05-08
Regulation of the artPIQM operon is controlled by the repressor argR (arginine repressor) and activated by high concentrations of Arginine. ArgR binds to the promoter, inhibiting crp from binding and transcribing the operon. Arginine is brought into the cell by the artPIQM transporter (which uses ATP and water). When arginine is in high concentration, argR releases the promoter, therefore allowing crp to bind to the promoter. The operon produces two transporters: artPQMJ and artPIQM used in arginine transport.
References
Arginine degradation; Arginine biosynthesis: artP, artI, artQ, artM References
Torres Montaguth OE, Bervoets I, Peeters E, Charlier D: Competitive Repression of the artPIQM Operon for Arginine and Ornithine Transport by Arginine Repressor and Leucine-Responsive Regulatory Protein in Escherichia coli. Front Microbiol. 2019 Jul 12;10:1563. doi: 10.3389/fmicb.2019.01563. eCollection 2019.
Pubmed: 31354664
Cho BK, Federowicz S, Park YS, Zengler K, Palsson BO: Deciphering the transcriptional regulatory logic of amino acid metabolism. Nat Chem Biol. 2011 Nov 13;8(1):65-71. doi: 10.1038/nchembio.710.
Pubmed: 22082910
Wissenbach U, Six S, Bongaerts J, Ternes D, Steinwachs S, Unden G: A third periplasmic transport system for L-arginine in Escherichia coli: molecular characterization of the artPIQMJ genes, arginine binding and transport. Mol Microbiol. 1995 Aug;17(4):675-86. doi: 10.1111/j.1365-2958.1995.mmi_17040675.x.
Pubmed: 8801422
Lim DB, Oppenheim JD, Eckhardt T, Maas WK: Nucleotide sequence of the argR gene of Escherichia coli K-12 and isolation of its product, the arginine repressor. Proc Natl Acad Sci U S A. 1987 Oct;84(19):6697-701. doi: 10.1073/pnas.84.19.6697.
Pubmed: 3116542
Caldara M, Minh PN, Bostoen S, Massant J, Charlier D: ArgR-dependent repression of arginine and histidine transport genes in Escherichia coli K-12. J Mol Biol. 2007 Oct 19;373(2):251-67. doi: 10.1016/j.jmb.2007.08.013. Epub 2007 Aug 21.
Pubmed: 17850814
Stirling CJ, Szatmari G, Stewart G, Smith MC, Sherratt DJ: The arginine repressor is essential for plasmid-stabilizing site-specific recombination at the ColE1 cer locus. EMBO J. 1988 Dec 20;7(13):4389-95.
Pubmed: 3149585
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Cossart P, Gicquel-Sanzey B: Cloning and sequence of the crp gene of Escherichia coli K 12. Nucleic Acids Res. 1982 Feb 25;10(4):1363-78. doi: 10.1093/nar/10.4.1363.
Pubmed: 6280141
Aiba H, Fujimoto S, Ozaki N: Molecular cloning and nucleotide sequencing of the gene for E. coli cAMP receptor protein. Nucleic Acids Res. 1982 Feb 25;10(4):1345-61. doi: 10.1093/nar/10.4.1345.
Pubmed: 6280140
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
Downloads
Settings