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Pathway Description
Methylglyoxal Degradation II
Escherichia coli IAI1
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2025-03-07
Last Updated: 2025-03-07
The most common pathway for methylglyoxal detoxification is the glyoxalase system, which is composed of two enzymes that together convert methylglyoxal to (R)-lactate in the presence of glutathione. However, in E. coli, a single enzyme, glyoxalase III, catalyzes this conversion in a single step without involvement of glutathione. Activity of glyoxalase III increases at the transition to stationary phase and expression is dependent on RpoS, suggesting that this pathway may be important during stationary phase. (EcoCyc)
References
Methylglyoxal Degradation II References
Campbell HD, Rogers BL, Young IG: Nucleotide sequence of the respiratory D-lactate dehydrogenase gene of Escherichia coli. Eur J Biochem. 1984 Oct 15;144(2):367-73. doi: 10.1111/j.1432-1033.1984.tb08473.x.
Pubmed: 6386470
Rule GS, Pratt EA, Chin CC, Wold F, Ho C: Overproduction and nucleotide sequence of the respiratory D-lactate dehydrogenase of Escherichia coli. J Bacteriol. 1985 Mar;161(3):1059-68.
Pubmed: 3882663
Kohn LD, Kaback HR: Mechanisms of active transport in isolated bacterial membrane vesicles. XV. Purification and properties of the membrane-bound D-lactate dehydrogenase from Escherichia coli. J Biol Chem. 1973 Oct 25;248(20):7012-7.
Pubmed: 4582730
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0002096
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