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Pathway Description
Methylglyoxal Degradation IV
Escherichia coli SE15
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2025-03-12
Last Updated: 2025-08-03
Methylglyoxal, also known as pyruvaldehyde, is a cytotoxic compound derived from pyruvic acid. In E. coli, there are at least eight pathways that are responsible for the detoxification of methylglyoxal. The first reaction in this pathway is the reduction of pyruvaldehyde to (S)-lactaldehyde, along with the cofactor NADH, catalyzed by 2,5-diketo-D-gluconic acid reductase subunits A and B. Following this, (S)-lactaldehyde is dehydrogenated into L-lactic acid by the lactaldehyde dehydrogenase enzyme, also using NAD as a cofactor. Finally, L-lactic acid is converted to pyruvic acid by L-lactate dehydrogenase in a reaction involving the reduction of an electron acceptor. Pyruvic acid is then used in glycolysis and pyruvate dehydrogenase pathways.
References
Methylglyoxal Degradation IV References
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. doi: 10.1038/msb4100049. Epub 2006 Feb 21.
Pubmed: 16738553
Yum DY, Lee BY, Pan JG: Identification of the yqhE and yafB genes encoding two 2, 5-diketo-D-gluconate reductases in Escherichia coli. Appl Environ Microbiol. 1999 Aug;65(8):3341-6.
Pubmed: 10427017
Sekiya T, Mori M, Takahashi N, Nishimura S: Sequence of the distal tRNA1Asp gene and the transcription termination signal in the Escherichia coli ribosomal RNA operon rrnF(or G). Nucleic Acids Res. 1980 Sep 11;8(17):3809-27. doi: 10.1093/nar/8.17.3809.
Pubmed: 6255418
Hidalgo E, Chen YM, Lin EC, Aguilar J: Molecular cloning and DNA sequencing of the Escherichia coli K-12 ald gene encoding aldehyde dehydrogenase. J Bacteriol. 1991 Oct;173(19):6118-23. doi: 10.1128/jb.173.19.6118-6123.1991.
Pubmed: 1917845
Aiba H, Baba T, Hayashi K, Inada T, Isono K, Itoh T, Kasai H, Kashimoto K, Kimura S, Kitakawa M, Kitagawa M, Makino K, Miki T, Mizobuchi K, Mori H, Mori T, Motomura K, Nakade S, Nakamura Y, Nashimoto H, Nishio Y, Oshima T, Saito N, Sampei G, Horiuchi T, et al.: A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. DNA Res. 1996 Dec 31;3(6):363-77. doi: 10.1093/dnares/3.6.363.
Pubmed: 9097039
Dong JM, Taylor JS, Latour DJ, Iuchi S, Lin EC: Three overlapping lct genes involved in L-lactate utilization by Escherichia coli. J Bacteriol. 1993 Oct;175(20):6671-8. doi: 10.1128/jb.175.20.6671-6678.1993.
Pubmed: 8407843
Sofia HJ, Burland V, Daniels DL, Plunkett G 3rd, Blattner FR: Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes. Nucleic Acids Res. 1994 Jul 11;22(13):2576-86. doi: 10.1093/nar/22.13.2576.
Pubmed: 8041620
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0002090
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