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Pathway Description
Ramoplanin resistance: ytrA, ytrB, ytrC, ytrD, ytrE, ytrF
Bacillus subtilis (strain 168)
Category:
Metabolite Pathway
Sub-Category:
Signaling
Created: 2025-03-25
Last Updated: 2025-07-01
The regulation of ytrABCDEF Operon. The operon is inhibited by ytrA (HTH-type transcriptional repressor) and activated indirectly by Ramoplanin. Ramoplanin indirectly inhibits ytrA by altering or damaging the peptidoglycan production. When there is peptidoglycan disruption, ytrA releases the promoter allowing crp to transcribe the operon. The operon has 6 products: ytrA, ytrB (ABC transporter ATP-binding protein), ytrC (Probable ABC transporter permease), ytrD (Probable ABC transporter permease), ytrE (ABC transporter ATP-binding protein) and ytrF (ABC transporter permease). All the products (not ytrA) form a transporter which is important for acetoin utilization.
References
Ramoplanin resistance: ytrA, ytrB, ytrC, ytrD, ytrE, ytrF References
Salzberg LI, Luo Y, Hachmann AB, Mascher T, Helmann JD: The Bacillus subtilis GntR family repressor YtrA responds to cell wall antibiotics. J Bacteriol. 2011 Oct;193(20):5793-801. doi: 10.1128/JB.05862-11. Epub 2011 Aug 19.
Pubmed: 21856850
Benda M, Schulz LM, Stulke J, Rismondo J: Influence of the ABC Transporter YtrBCDEF of Bacillus subtilis on Competence, Biofilm Formation and Cell Wall Thickness. Front Microbiol. 2021 Apr 8;12:587035. doi: 10.3389/fmicb.2021.587035. eCollection 2021.
Pubmed: 33897624
Yoshida KI, Fujita Y, Ehrlich SD: An operon for a putative ATP-binding cassette transport system involved in acetoin utilization of Bacillus subtilis. J Bacteriol. 2000 Oct;182(19):5454-61. doi: 10.1128/JB.182.19.5454-5461.2000.
Pubmed: 10986249
Cossart P, Gicquel-Sanzey B: Cloning and sequence of the crp gene of Escherichia coli K 12. Nucleic Acids Res. 1982 Feb 25;10(4):1363-78. doi: 10.1093/nar/10.4.1363.
Pubmed: 6280141
Aiba H, Fujimoto S, Ozaki N: Molecular cloning and nucleotide sequencing of the gene for E. coli cAMP receptor protein. Nucleic Acids Res. 1982 Feb 25;10(4):1345-61. doi: 10.1093/nar/10.4.1345.
Pubmed: 6280140
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
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