PathBank

Pathway Description

Inositol utilization: iolR, iolS

Bacillus subtilis (strain 168)

Category:

Metabolite Pathway

Sub-Category:

Signaling

Created: 2025-03-25

Last Updated: 2025-09-13

The regulation of the iolRS operon. The operon is inhibited by iolR (HTH-type transcriptional regulator) and activated by the presence of inositol. Glucose can also contribute to the inhibition of the operon. The operon has two products: iolR and iolS (Aldo-keto reductase). The function of iolS is unknown.

References

Inositol utilization: iolR, iolS References

Kang DM, Michon C, Morinaga T, Tanaka K, Takenaka S, Ishikawa S, Yoshida KI: Bacillus subtilis IolQ (DegA) is a transcriptional repressor of iolX encoding NAD(+)-dependent scyllo-inositol dehydrogenase. BMC Microbiol. 2017 Jul 11;17(1):154. doi: 10.1186/s12866-017-1065-8.

Pubmed: 28693424

Yoshida KI, Aoyama D, Ishio I, Shibayama T, Fujita Y: Organization and transcription of the myo-inositol operon, iol, of Bacillus subtilis. J Bacteriol. 1997 Jul;179(14):4591-8. doi: 10.1128/jb.179.14.4591-4598.1997.

Pubmed: 9226270

Kohler PR, Choong EL, Rossbach S: The RpiR-like repressor IolR regulates inositol catabolism in Sinorhizobium meliloti. J Bacteriol. 2011 Oct;193(19):5155-63. doi: 10.1128/JB.05371-11. Epub 2011 Jul 22.

Pubmed: 21784930

Cossart P, Gicquel-Sanzey B: Cloning and sequence of the crp gene of Escherichia coli K 12. Nucleic Acids Res. 1982 Feb 25;10(4):1363-78. doi: 10.1093/nar/10.4.1363.

Pubmed: 6280141

Aiba H, Fujimoto S, Ozaki N: Molecular cloning and nucleotide sequencing of the gene for E. coli cAMP receptor protein. Nucleic Acids Res. 1982 Feb 25;10(4):1345-61. doi: 10.1093/nar/10.4.1345.

Pubmed: 6280140

Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.

Pubmed: 9278503

Highlighted elements will appear in red.

Highlight Compounds

	D-Glucose
	Inositol

Highlight Proteins

	Aldo-keto reductase IolS
	cAMP-activated global transcriptional regulator CRP
	HTH-type transcriptional regulator IolR
	Major myo-inositol transporter IolT

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