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Pathway Description
Galactan utilization: ganS, ganP, ganQ, ganA, ganB
Bacillus subtilis (strain 168)
Category:
Metabolite Pathway
Sub-Category:
Signaling
Created: 2025-03-25
Last Updated: 2025-07-22
The regulation of the ganSPQAB operon. The operon is inhibited by ganR (HTH-type transcriptional regulator) and glucose. The operon in activated by the presence of galactobiose which is transported into the cell by the ganSPQ transporter. GanR bind to the promoter, inhibiting the expression of the operon. When galactobiose is present, it binds to ganR causing it to release the promoter. The operon has five products: ganS (Galactooligosaccharide-binding protein), ganP (Galactooligosaccharides transport system permease protein), ganQ (Galactooligosaccharides transport system permease protein), ganA (Beta-galactosidase) and ganB (O07013). GanS, ganP, ganQ and msmX (Oligosaccharides import ATP-binding protein) form an ABC transporter involved in the transport of galactobiose into the cell. The other two products are enzymes used in the utilization of galactan (galactan to galactose). GanB is used to turn galactan to galactobiose in the extracellular space (the enzyme is secreted out of the cell). GanA is used to turn galactobiose to galactose inside the cell.
References
Galactan utilization: ganS, ganP, ganQ, ganA, ganB References
Watzlawick H, Morabbi Heravi K, Altenbuchner J: Role of the ganSPQAB Operon in Degradation of Galactan by Bacillus subtilis. J Bacteriol. 2016 Sep 22;198(20):2887-96. doi: 10.1128/JB.00468-16. Print 2016 Oct 15.
Pubmed: 27501980
Cossart P, Gicquel-Sanzey B: Cloning and sequence of the crp gene of Escherichia coli K 12. Nucleic Acids Res. 1982 Feb 25;10(4):1363-78. doi: 10.1093/nar/10.4.1363.
Pubmed: 6280141
Aiba H, Fujimoto S, Ozaki N: Molecular cloning and nucleotide sequencing of the gene for E. coli cAMP receptor protein. Nucleic Acids Res. 1982 Feb 25;10(4):1345-61. doi: 10.1093/nar/10.4.1345.
Pubmed: 6280140
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
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