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Pathway Description
Galactonate utilization: dgoR, dgoK, dgoA, dgoD, dgoT
Escherichia coli K-12
Category:
Metabolite Pathway
Sub-Category:
Signaling
Created: 2025-03-25
Last Updated: 2025-07-01
The regulation of the dgoRKADT operon. The operon is inhibited by dgoR (Galactonate operon transcriptional repressor) and activated by galactonate. DgoR inhibits the operon by binding to two closely spaced inverted repeats in the cis-acting element, which overlap with the D-galactonate responsive dgo promoter. When galactonate is present, it binds to dgoR, causing conformational changes resulting in dgoR releasing the promoter. The operon has five products: dgoR, dgoK (2-dehydro-3-deoxygalactonokinase), dgoA (2-dehydro-3-deoxy-6-phosphogalactonate aldolase), dgoD (D-galactonate dehydratase) and dgoT (D-galactonate transporter). DgoK, dgoA and dgoD are enzymes used in the utilization of galactonate (galactonate to pyruvate and D-glyceraidehyde-3-phosphate). Galactonate is brought into the cell by dgoT transporter. DgoD is used to turn galactonate to 2-dehydro-3-deoxy-D-galactonate. DgoK is used to turn 2-dehydro-3-deoxy-D-galactonate to 2-dehydro-3-deoxy-D-galactonate-6-phosphate. DgoA is used to turn 2-dehydro-3-deoxy-D-galactonate-6-phosphate to pyruvate and D-glyceraidehyde-3-phosphate.
References
Galactonate utilization: dgoR, dgoK, dgoA, dgoD, dgoT References
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