PathBank

Pathway Description

tRNA Charging

Providencia stuartii ATCC 25827

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2024-12-18

Last Updated: 2025-07-10

This pathway is a compilation of Escherichia coli tRNA charging reactions involving amino acids transported into the cell. The aminoacyl-tRNA synthetase is an enzyme that attaches the appropriate amino acid onto its tRNA by catalyzing the esterification of a specific cognate amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA, which plays an important role in RNA translation. 20 different Aminoacyl-tRNA synthetases can make 20 different types of aa-tRNA for each amino acid according to the genetic code. This process is called "charging" or "loading" the tRNA with amino acid. Ribosome can transfer the amino acid from tRNA to a growing peptide after the tRNA is charged.

References

tRNA Charging References

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0000820

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Adenosine diphosphate
		Adenosine monophosphate
		Adenosine triphosphate
		Glycine
		Hydrogen Ion
		L-Alanine
		L-Arginine
		L-Asparagine
		L-Aspartic acid
		L-Cysteine
		L-Glutamic acid
		L-Glutamine
		L-Histidine
		L-Isoleucine
		L-Leucine
		L-Lysine
		L-Methionine
		L-Phenylalanine
		L-Proline
		L-Serine
		L-Threonine
		L-Tryptophan
		L-Tyrosine
		L-Valine
		Phosphate
		Pyrophosphate
		Water

Visualize Protein Data

		ABC transporter, ATP-binding protein
		ABC transporter, ATP-binding protein
		ABC transporter, permease protein
		ABC transporter, substrate-binding protein, family 3
		ABC transporter, substrate-binding protein, QAT family
		Amino acid permease
		Amino acid permease
		Arginine ABC transporter permease protein ArtM
		Arginine ABC transporter permease protein ArtQ
		Arginine transport ATP-binding protein ArtP
		ATP synthase F0, A subunit
		ATP-dependent Clp protease ATP-binding subunit ClpA
		Branched-chain amino acid ABC transporter, permease protein
		Branched-chain amino acid transporter permease subunit LivH
		D-methionine transport system permease protein MetI
		DUF3686 domain-containing protein
		Elongation factor P--(R)-beta-lysine ligase
		Fatty acid metabolism regulator protein
		Glutamate--tRNA ligase
		Glutamate/aspartate transport system permease protein GltK
		Glutamyl-Q tRNA(Asp) synthetase
		glycerophosphodiester phosphodiesterase
		High-affinity branched-chain amino acid transport ATP-binding protein
		High-affinity branched-chain amino acid transport ATP-binding protein LivG
		Isoleucine--tRNA ligase
		L-methionine gamma-lyase
		Leucine--tRNA ligase
		Lipoprotein
		Lysine--tRNA ligase
		Lysine-arginine-ornithine-binding periplasmic protein
		Phosphoenolpyruvate-protein phosphotransferase
		Proline--tRNA ligase
		Rhs element Vgr protein
		Serine transporter
		Spermidine/putrescine import ATP-binding protein PotA
		Threonine--tRNA ligase
		Threonine/alanine tRNA ligase second additional domain protein
		Uncharacterized protein
		Valine--tRNA ligase