PathBank

Pathway Description

tRNA Charging

Haemophilus haemolyticus M19501

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2024-12-18

Last Updated: 2025-07-10

This pathway is a compilation of Escherichia coli tRNA charging reactions involving amino acids transported into the cell. The aminoacyl-tRNA synthetase is an enzyme that attaches the appropriate amino acid onto its tRNA by catalyzing the esterification of a specific cognate amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA, which plays an important role in RNA translation. 20 different Aminoacyl-tRNA synthetases can make 20 different types of aa-tRNA for each amino acid according to the genetic code. This process is called "charging" or "loading" the tRNA with amino acid. Ribosome can transfer the amino acid from tRNA to a growing peptide after the tRNA is charged.

References

tRNA Charging References

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0000820

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Adenosine diphosphate
		Adenosine monophosphate
		Adenosine triphosphate
		Glycine
		Hydrogen Ion
		L-Alanine
		L-Arginine
		L-Asparagine
		L-Aspartic acid
		L-Cysteine
		L-Glutamic acid
		L-Glutamine
		L-Histidine
		L-Isoleucine
		L-Leucine
		L-Lysine
		L-Methionine
		L-Phenylalanine
		L-Proline
		L-Serine
		L-Threonine
		L-Tryptophan
		L-Tyrosine
		L-Valine
		Phosphate
		Pyrophosphate
		Water

Visualize Protein Data

		ABC transporter arginine-binding protein
		Arginine ABC transporter permease protein ArtM
		Arginine ABC transporter permease protein ArtQ
		Arginine transport ATP-binding protein ArtP
		Aspartate--tRNA ligase
		Bacterial extracellular solute-binding protein
		Chaperone protein DnaK
		Conserved inner membrane protein
		Der GTPase-activating protein YihI
		Elongation factor P--(R)-beta-lysine ligase
		Galactoside transport system permease protein mglC
		Glutamate--tRNA ligase
		Glutamine--tRNA ligase
		Isoleucine--tRNA ligase
		Leucine--tRNA ligase
		Lipopolysaccharide export system ATP-binding protein LptB
		Lipoprotein
		Lysine--tRNA ligase
		Methionine import ATP-binding protein MetN
		Peptidyl-tRNA hydrolase
		Proline--tRNA ligase
		protein-N(pi)-phosphohistidine--D-fructose phosphotransferase
		Putative ABC transporter permease protein
		Putative amino-acid ABC transporter ATP-binding protein
		Putative amino-acid ABC transporter permease protein
		Putative D-methionine transport system permease protein metI
		Putative hep/Hag
		Putative oligopeptide transporter
		Putative peptidase S13, D-Ala-D-Ala carboxypeptidase C
		RNA polymerase-associated protein RapA
		Serine transporter
		Spermidine/putrescine import ATP-binding protein PotA
		Threonine--tRNA ligase
		TonB-dependent heme receptor A
		Transporter
		Tyrosine--tRNA ligase
		Unknown
		Valine--tRNA ligase