The biosynthesis of dTDP-L-rhamnose involves a sequence of enzymatic processes that take place within the cytoplasm. D-glucose-1-phosphate, a precursor molecule for dTDP-L-rhamnose biosynthesis, is produced by key metabolic pathways such as glycolysis within the bacterial cell. The enzyme dTDP-glucose pyrophosphorylase converts D-glucose-1-phosphate to dTDP-glucose, which is then converted by the enzyme dTDP-glucose 4,6-dehydratase to 4,6-Dideoxy-4-oxo-dTDP-D-glucose. The enzyme dTDP-4-dehydrorhamnose 3,5-epimerase then converts 4,6-Dideoxy-4-oxo-dTDP-D-glucose into dTDP-4-oxo-L-rhamnose. Finally, dTDP-4-dehydrorhamnose reductase converts it to dTDP-L-rhamnose. The production of dTDP-L-rhamnose is required for many cellular functions, including streptomycin biosynthesis.

dTDP-L-rhamnose biosynthesis References