YvfT/YvfU controls the expression of the yvfRS operon that codes for an ABC transporter. The YvfT effector pathway is part of a two-component signal transduction system that enables bacterial cells to sense and respond to environmental stimuli. This system is governed by the YvfU regulog, in which YvfU acts as the response regulator, and YvfT functions as the sensor histidine kinase. In this pathway: YvfT – A sensor histidine kinase located in the cell membrane, YvfT detects specific extracellular signals (likely related to stress, nutrient availability, or other environmental conditions). Upon signal detection, YvfT undergoes autophosphorylation at a conserved histidine residue. YvfU – A response regulator that receives the phosphate group from phosphorylated YvfT. Once activated, YvfU binds DNA to regulate the transcription of target genes in the pathway. yvfR – Encodes a putative membrane-associated protein that may play a role in signal transduction or cellular response. yvfS – Encodes a protein of unknown function, possibly involved in the same regulatory network or contributing to the downstream response. BLi04302 – A gene with currently uncharacterized function, but often found in operonic association with the yvf cluster, suggesting it may contribute to the physiological response triggered by the YvfT/YvfU system.

YvfT operon References