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Pathway Description
Galactose utilization: galE, galT, galK, galM
Bacillus subtilis
Category:
Metabolite Pathway
Sub-Category:
Signaling
Created: 2025-07-09
Last Updated: 2025-07-09
The regulation of the galETKM operon. The operon is inhibited by galR (HTH-type transcriptional regulator) and activated by galactose. The presence of galactose causes galR to release the promoter, allowing transcription of the operon. The operon has four products: galE (UDP-glucose 4-epimerase), galT (Galactose-1-phosphate uridylyltransferase), galK (Galactokinase) and galM (Aldose 1-epimerase). All of these products are enzymes used in the utilization of galactose (galactose to UDP-galactose). GalK is used to turn galactose to galactose-1-phosphate. GalT is used to turn UDP-glucose to UDP-galactose, while galE catalyzes the reverse reaction. GalM is used to change alpha-D-glucose to beta-D-glucose.
References
Galactose utilization: galE, galT, galK, galM References
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0565310
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