N-(3-Oxodecanoyl)-L-homoserine lactone (3-oxo-C10-HSL), though not extensively studied, bears structural similarity to N-3-Oxo-Dodecanoyl-L-Homoserine Lactone (3-oxo-C12-HSL), but with a shorter acyl chain. Similar to 3-oxo-C12-HSL, it serves as a critical signaling molecule in Pseudomonas aeruginosa's quorum sensing (QS) system. Upon reaching a sufficient concentration, 3-oxo-C10-HSL activates the transcription factor LasR, which then binds to specific promoter regions to initiate the transcription of the psl operon. This operon encodes the enzymes responsible for synthesizing the polysaccharide Psl (polysaccharide intercellular adhesin), which plays an essential role in the formation of biofilms. The Psl polysaccharide facilitates cell adhesion and contributes to the structural integrity of the biofilm, promoting the establishment and maintenance of bacterial communities. Through this intricate signaling cascade, 3-oxo-C10-HSL not only enhances the production of Psl but also underscores the sophisticated mechanisms by which bacteria coordinate their collective behavior in response to changing environments, ultimately leading to more robust biofilm formation.

Quorum sensing: N-(3-Oxodecanoyl)-L-homoserine lactone Biofilm Regulation References