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Showing 227581 - 227590 of 605359 pathways

PathBank ID	Pathway Name and Description	Pathway Class	Chemical Compounds	Proteins
SMP0122392 View Pathway	Rhamnolipid Biosynthesis RL(8:0(3-OH)/12:1(3-OH,5Z)) Pseudomonas aeruginosa Rhamnolipids (RL) consist of a fatty acyl moiety composed of a 3-(3-hydroxyalkanoyloxy)alkaloid acid (HAA) and a sugar moiety composed of one or two rhamnose sugars. Rhamnolipids function as surfactants and virulence factors and are involved in biofilm formation and cell motility. The rhamnose sugar component is produced via the dTDP-L-rhamnose biosynthetic pathway which forms dTDP-L-rhamnose from glucose 6-phosphate (G6P) in five steps. First, glucose 6-phosphate is converted into glucose 1-phosphate (G1P) via the enzyme phosphoglucomutase (AlgC). Second, glucose 1-phosphate is converted into dTDP-D-glucose via the enzyme glucose-1-phosphate thymidylyltransferase (RmlA). Third, dTDP-D-glucose is converted into dTDP-4-dehydro-6-deoxy-D-glucose via the enzyme dTDP-glucose 4,6-dehydratase (RmlB). Fourth, dTDP-4-dehydro-6-deoxy-D-glucose is converted into dTDP-4-dehydro-L-rhamnose via the enzyme dTDP-4-dehydrorhamnose 3,5-epimerase (RmlC). Fifth, dTDP-4-dehydro-L-rhamnose is converted into dTDP-L-rhamnose via the enzyme dTDP-4-dehydrorhamnose reductase (RmlD). The HAA component is synthesized from 3-hydroxyacyl-[acyl-carrier protein] diverted from fatty acid biosynthesis via the enzyme 3-(3-hydroxydecanoyloxy)decanoate synthase (RhIA). The final step in rhamnolipid biosynthesis is the formation of the glycosidic link between the rhamnose sugar component and the HAA component. This is accomplished by two rhamnosyltransferases (RhlB and RhlC) which catalyze sequential glycosyl transfer reactions to first form mono-rhamnolipids (via RhIB) and then di-rhamnolipids (via RhIC). RHlA, RHlB, and RHlC are associated with the inner membrane. BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolite Metabolic	diRL(8:0(3-OH)/12:1(3-OH,5Z)) dTDP dTDP-4-dehydro-6-deoxy-D-gluco... dTDP-4-dehydro-β-L-rhamnose dTDP-D-glucose dTDP-β-L-rhamnose Glucose 1-phosphate Glucose 6-phosphate HAA(8:0(3-OH)/12:1(3-OH,5Z)) Hydrogen Ion Magnesium monoRL(8:0(3-OH)/12:1(3-OH,5Z)... NAD NADP NADPH Pyrophosphate Thymidine 5'-triphosphate Water ( show all show less )	3-(3-Hydroxydecanoyloxy)decano... dTDP-4-dehydrorhamnose 3,5-epi... dTDP-4-dehydrorhamnose reducta... dTDP-glucose 4,6-dehydratase Glucose-1-phosphate thymidylyl... Phosphomannomutase/phosphogluc... Rhamnosyltransferase 2 Rhamnosyltransferase chain B ( show all show less )
SMP0122393 View Pathway	Rhamnolipid Biosynthesis RL(8:0(3-OH)/12:1(3-OH,6Z)) Pseudomonas aeruginosa Rhamnolipids (RL) consist of a fatty acyl moiety composed of a 3-(3-hydroxyalkanoyloxy)alkaloid acid (HAA) and a sugar moiety composed of one or two rhamnose sugars. Rhamnolipids function as surfactants and virulence factors and are involved in biofilm formation and cell motility. The rhamnose sugar component is produced via the dTDP-L-rhamnose biosynthetic pathway which forms dTDP-L-rhamnose from glucose 6-phosphate (G6P) in five steps. First, glucose 6-phosphate is converted into glucose 1-phosphate (G1P) via the enzyme phosphoglucomutase (AlgC). Second, glucose 1-phosphate is converted into dTDP-D-glucose via the enzyme glucose-1-phosphate thymidylyltransferase (RmlA). Third, dTDP-D-glucose is converted into dTDP-4-dehydro-6-deoxy-D-glucose via the enzyme dTDP-glucose 4,6-dehydratase (RmlB). Fourth, dTDP-4-dehydro-6-deoxy-D-glucose is converted into dTDP-4-dehydro-L-rhamnose via the enzyme dTDP-4-dehydrorhamnose 3,5-epimerase (RmlC). Fifth, dTDP-4-dehydro-L-rhamnose is converted into dTDP-L-rhamnose via the enzyme dTDP-4-dehydrorhamnose reductase (RmlD). The HAA component is synthesized from 3-hydroxyacyl-[acyl-carrier protein] diverted from fatty acid biosynthesis via the enzyme 3-(3-hydroxydecanoyloxy)decanoate synthase (RhIA). The final step in rhamnolipid biosynthesis is the formation of the glycosidic link between the rhamnose sugar component and the HAA component. This is accomplished by two rhamnosyltransferases (RhlB and RhlC) which catalyze sequential glycosyl transfer reactions to first form mono-rhamnolipids (via RhIB) and then di-rhamnolipids (via RhIC). RHlA, RHlB, and RHlC are associated with the inner membrane. BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolite Metabolic	diRL(8:0(3-OH)/12:1(3-OH,6Z)) dTDP dTDP-4-dehydro-6-deoxy-D-gluco... dTDP-4-dehydro-β-L-rhamnose dTDP-D-glucose dTDP-β-L-rhamnose Glucose 1-phosphate Glucose 6-phosphate HAA(8:0(3-OH)/12:1(3-OH,6Z)) Hydrogen Ion Magnesium monoRL(8:0(3-OH)/12:1(3-OH,6Z)... NAD NADP NADPH Pyrophosphate Thymidine 5'-triphosphate Water ( show all show less )	3-(3-Hydroxydecanoyloxy)decano... dTDP-4-dehydrorhamnose 3,5-epi... dTDP-4-dehydrorhamnose reducta... dTDP-glucose 4,6-dehydratase Glucose-1-phosphate thymidylyl... Phosphomannomutase/phosphogluc... Rhamnosyltransferase 2 Rhamnosyltransferase chain B ( show all show less )
SMP0122394 View Pathway	Rhamnolipid Biosynthesis RL(8:0(3-OH)/14:1(3-OH,5Z)) Pseudomonas aeruginosa Rhamnolipids (RL) consist of a fatty acyl moiety composed of a 3-(3-hydroxyalkanoyloxy)alkaloid acid (HAA) and a sugar moiety composed of one or two rhamnose sugars. Rhamnolipids function as surfactants and virulence factors and are involved in biofilm formation and cell motility. The rhamnose sugar component is produced via the dTDP-L-rhamnose biosynthetic pathway which forms dTDP-L-rhamnose from glucose 6-phosphate (G6P) in five steps. First, glucose 6-phosphate is converted into glucose 1-phosphate (G1P) via the enzyme phosphoglucomutase (AlgC). Second, glucose 1-phosphate is converted into dTDP-D-glucose via the enzyme glucose-1-phosphate thymidylyltransferase (RmlA). Third, dTDP-D-glucose is converted into dTDP-4-dehydro-6-deoxy-D-glucose via the enzyme dTDP-glucose 4,6-dehydratase (RmlB). Fourth, dTDP-4-dehydro-6-deoxy-D-glucose is converted into dTDP-4-dehydro-L-rhamnose via the enzyme dTDP-4-dehydrorhamnose 3,5-epimerase (RmlC). Fifth, dTDP-4-dehydro-L-rhamnose is converted into dTDP-L-rhamnose via the enzyme dTDP-4-dehydrorhamnose reductase (RmlD). The HAA component is synthesized from 3-hydroxyacyl-[acyl-carrier protein] diverted from fatty acid biosynthesis via the enzyme 3-(3-hydroxydecanoyloxy)decanoate synthase (RhIA). The final step in rhamnolipid biosynthesis is the formation of the glycosidic link between the rhamnose sugar component and the HAA component. This is accomplished by two rhamnosyltransferases (RhlB and RhlC) which catalyze sequential glycosyl transfer reactions to first form mono-rhamnolipids (via RhIB) and then di-rhamnolipids (via RhIC). RHlA, RHlB, and RHlC are associated with the inner membrane. BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolite Metabolic	diRL(8:0(3-OH)/14:1(3-OH,5Z)) dTDP dTDP-4-dehydro-6-deoxy-D-gluco... dTDP-4-dehydro-β-L-rhamnose dTDP-D-glucose dTDP-β-L-rhamnose Glucose 1-phosphate Glucose 6-phosphate HAA(8:0(3-OH)/14:1(3-OH,5Z)) Hydrogen Ion Magnesium monoRL(8:0(3-OH)/14:1(3-OH,5Z)... NAD NADP NADPH Pyrophosphate Thymidine 5'-triphosphate Water ( show all show less )	3-(3-Hydroxydecanoyloxy)decano... dTDP-4-dehydrorhamnose 3,5-epi... dTDP-4-dehydrorhamnose reducta... dTDP-glucose 4,6-dehydratase Glucose-1-phosphate thymidylyl... Phosphomannomutase/phosphogluc... Rhamnosyltransferase 2 Rhamnosyltransferase chain B ( show all show less )
SMP0122395 View Pathway	Rhamnolipid Biosynthesis RL(8:0(3-OH)/14:1(3-OH,7Z)) Pseudomonas aeruginosa Rhamnolipids (RL) consist of a fatty acyl moiety composed of a 3-(3-hydroxyalkanoyloxy)alkaloid acid (HAA) and a sugar moiety composed of one or two rhamnose sugars. Rhamnolipids function as surfactants and virulence factors and are involved in biofilm formation and cell motility. The rhamnose sugar component is produced via the dTDP-L-rhamnose biosynthetic pathway which forms dTDP-L-rhamnose from glucose 6-phosphate (G6P) in five steps. First, glucose 6-phosphate is converted into glucose 1-phosphate (G1P) via the enzyme phosphoglucomutase (AlgC). Second, glucose 1-phosphate is converted into dTDP-D-glucose via the enzyme glucose-1-phosphate thymidylyltransferase (RmlA). Third, dTDP-D-glucose is converted into dTDP-4-dehydro-6-deoxy-D-glucose via the enzyme dTDP-glucose 4,6-dehydratase (RmlB). Fourth, dTDP-4-dehydro-6-deoxy-D-glucose is converted into dTDP-4-dehydro-L-rhamnose via the enzyme dTDP-4-dehydrorhamnose 3,5-epimerase (RmlC). Fifth, dTDP-4-dehydro-L-rhamnose is converted into dTDP-L-rhamnose via the enzyme dTDP-4-dehydrorhamnose reductase (RmlD). The HAA component is synthesized from 3-hydroxyacyl-[acyl-carrier protein] diverted from fatty acid biosynthesis via the enzyme 3-(3-hydroxydecanoyloxy)decanoate synthase (RhIA). The final step in rhamnolipid biosynthesis is the formation of the glycosidic link between the rhamnose sugar component and the HAA component. This is accomplished by two rhamnosyltransferases (RhlB and RhlC) which catalyze sequential glycosyl transfer reactions to first form mono-rhamnolipids (via RhIB) and then di-rhamnolipids (via RhIC). RHlA, RHlB, and RHlC are associated with the inner membrane. BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolite Metabolic	diRL(8:0(3-OH)/14:1(3-OH,7Z)) dTDP dTDP-4-dehydro-6-deoxy-D-gluco... dTDP-4-dehydro-β-L-rhamnose dTDP-D-glucose dTDP-β-L-rhamnose Glucose 1-phosphate Glucose 6-phosphate HAA(8:0(3-OH)/14:1(3-OH,7Z)) Hydrogen Ion Magnesium monoRL(8:0(3-OH)/14:1(3-OH,7Z)... NAD NADP NADPH Pyrophosphate Thymidine 5'-triphosphate Water ( show all show less )	3-(3-Hydroxydecanoyloxy)decano... dTDP-4-dehydrorhamnose 3,5-epi... dTDP-4-dehydrorhamnose reducta... dTDP-glucose 4,6-dehydratase Glucose-1-phosphate thymidylyl... Phosphomannomutase/phosphogluc... Rhamnosyltransferase 2 Rhamnosyltransferase chain B ( show all show less )
SMP0122396 View Pathway	Rhamnolipid Biosynthesis RL(8:0(3-OH)/16:1(3-OH,9Z)) Pseudomonas aeruginosa Rhamnolipids (RL) consist of a fatty acyl moiety composed of a 3-(3-hydroxyalkanoyloxy)alkaloid acid (HAA) and a sugar moiety composed of one or two rhamnose sugars. Rhamnolipids function as surfactants and virulence factors and are involved in biofilm formation and cell motility. The rhamnose sugar component is produced via the dTDP-L-rhamnose biosynthetic pathway which forms dTDP-L-rhamnose from glucose 6-phosphate (G6P) in five steps. First, glucose 6-phosphate is converted into glucose 1-phosphate (G1P) via the enzyme phosphoglucomutase (AlgC). Second, glucose 1-phosphate is converted into dTDP-D-glucose via the enzyme glucose-1-phosphate thymidylyltransferase (RmlA). Third, dTDP-D-glucose is converted into dTDP-4-dehydro-6-deoxy-D-glucose via the enzyme dTDP-glucose 4,6-dehydratase (RmlB). Fourth, dTDP-4-dehydro-6-deoxy-D-glucose is converted into dTDP-4-dehydro-L-rhamnose via the enzyme dTDP-4-dehydrorhamnose 3,5-epimerase (RmlC). Fifth, dTDP-4-dehydro-L-rhamnose is converted into dTDP-L-rhamnose via the enzyme dTDP-4-dehydrorhamnose reductase (RmlD). The HAA component is synthesized from 3-hydroxyacyl-[acyl-carrier protein] diverted from fatty acid biosynthesis via the enzyme 3-(3-hydroxydecanoyloxy)decanoate synthase (RhIA). The final step in rhamnolipid biosynthesis is the formation of the glycosidic link between the rhamnose sugar component and the HAA component. This is accomplished by two rhamnosyltransferases (RhlB and RhlC) which catalyze sequential glycosyl transfer reactions to first form mono-rhamnolipids (via RhIB) and then di-rhamnolipids (via RhIC). RHlA, RHlB, and RHlC are associated with the inner membrane. BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolite Metabolic	diRL(8:0(3-OH)/16:1(3-OH,9Z)) dTDP dTDP-4-dehydro-6-deoxy-D-gluco... dTDP-4-dehydro-β-L-rhamnose dTDP-D-glucose dTDP-β-L-rhamnose Glucose 1-phosphate Glucose 6-phosphate HAA(8:0(3-OH)/16:1(3-OH,9Z)) Hydrogen Ion Magnesium monoRL(8:0(3-OH)/16:1(3-OH,9Z)... NAD NADP NADPH Pyrophosphate Thymidine 5'-triphosphate Water ( show all show less )	3-(3-Hydroxydecanoyloxy)decano... dTDP-4-dehydrorhamnose 3,5-epi... dTDP-4-dehydrorhamnose reducta... dTDP-glucose 4,6-dehydratase Glucose-1-phosphate thymidylyl... Phosphomannomutase/phosphogluc... Rhamnosyltransferase 2 Rhamnosyltransferase chain B ( show all show less )
SMP0122388 View Pathway	Rhamnolipid Biosynthesis RL(8:0(3-OH)/6:0(3-OH)) Pseudomonas aeruginosa Rhamnolipids (RL) consist of a fatty acyl moiety composed of a 3-(3-hydroxyalkanoyloxy)alkaloid acid (HAA) and a sugar moiety composed of one or two rhamnose sugars. Rhamnolipids function as surfactants and virulence factors and are involved in biofilm formation and cell motility. The rhamnose sugar component is produced via the dTDP-L-rhamnose biosynthetic pathway which forms dTDP-L-rhamnose from glucose 6-phosphate (G6P) in five steps. First, glucose 6-phosphate is converted into glucose 1-phosphate (G1P) via the enzyme phosphoglucomutase (AlgC). Second, glucose 1-phosphate is converted into dTDP-D-glucose via the enzyme glucose-1-phosphate thymidylyltransferase (RmlA). Third, dTDP-D-glucose is converted into dTDP-4-dehydro-6-deoxy-D-glucose via the enzyme dTDP-glucose 4,6-dehydratase (RmlB). Fourth, dTDP-4-dehydro-6-deoxy-D-glucose is converted into dTDP-4-dehydro-L-rhamnose via the enzyme dTDP-4-dehydrorhamnose 3,5-epimerase (RmlC). Fifth, dTDP-4-dehydro-L-rhamnose is converted into dTDP-L-rhamnose via the enzyme dTDP-4-dehydrorhamnose reductase (RmlD). The HAA component is synthesized from 3-hydroxyacyl-[acyl-carrier protein] diverted from fatty acid biosynthesis via the enzyme 3-(3-hydroxydecanoyloxy)decanoate synthase (RhIA). The final step in rhamnolipid biosynthesis is the formation of the glycosidic link between the rhamnose sugar component and the HAA component. This is accomplished by two rhamnosyltransferases (RhlB and RhlC) which catalyze sequential glycosyl transfer reactions to first form mono-rhamnolipids (via RhIB) and then di-rhamnolipids (via RhIC). RHlA, RHlB, and RHlC are associated with the inner membrane. BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolite Metabolic	diRL(8:0(3-OH)/6:0(3-OH)) dTDP dTDP-4-dehydro-6-deoxy-D-gluco... dTDP-4-dehydro-β-L-rhamnose dTDP-D-glucose dTDP-β-L-rhamnose Glucose 1-phosphate Glucose 6-phosphate HAA(8:0(3-OH)/6:0(3-OH)) Hydrogen Ion Magnesium monoRL(8:0(3-OH)/6:0(3-OH)) NAD NADP NADPH Pyrophosphate Thymidine 5'-triphosphate Water ( show all show less )	3-(3-Hydroxydecanoyloxy)decano... dTDP-4-dehydrorhamnose 3,5-epi... dTDP-4-dehydrorhamnose reducta... dTDP-glucose 4,6-dehydratase Glucose-1-phosphate thymidylyl... Phosphomannomutase/phosphogluc... Rhamnosyltransferase 2 Rhamnosyltransferase chain B ( show all show less )
SMP0122389 View Pathway	Rhamnolipid Biosynthesis RL(8:0(3-OH)/8:0(3-OH)) Pseudomonas aeruginosa Rhamnolipids (RL) consist of a fatty acyl moiety composed of a 3-(3-hydroxyalkanoyloxy)alkaloid acid (HAA) and a sugar moiety composed of one or two rhamnose sugars. Rhamnolipids function as surfactants and virulence factors and are involved in biofilm formation and cell motility. The rhamnose sugar component is produced via the dTDP-L-rhamnose biosynthetic pathway which forms dTDP-L-rhamnose from glucose 6-phosphate (G6P) in five steps. First, glucose 6-phosphate is converted into glucose 1-phosphate (G1P) via the enzyme phosphoglucomutase (AlgC). Second, glucose 1-phosphate is converted into dTDP-D-glucose via the enzyme glucose-1-phosphate thymidylyltransferase (RmlA). Third, dTDP-D-glucose is converted into dTDP-4-dehydro-6-deoxy-D-glucose via the enzyme dTDP-glucose 4,6-dehydratase (RmlB). Fourth, dTDP-4-dehydro-6-deoxy-D-glucose is converted into dTDP-4-dehydro-L-rhamnose via the enzyme dTDP-4-dehydrorhamnose 3,5-epimerase (RmlC). Fifth, dTDP-4-dehydro-L-rhamnose is converted into dTDP-L-rhamnose via the enzyme dTDP-4-dehydrorhamnose reductase (RmlD). The HAA component is synthesized from 3-hydroxyacyl-[acyl-carrier protein] diverted from fatty acid biosynthesis via the enzyme 3-(3-hydroxydecanoyloxy)decanoate synthase (RhIA). The final step in rhamnolipid biosynthesis is the formation of the glycosidic link between the rhamnose sugar component and the HAA component. This is accomplished by two rhamnosyltransferases (RhlB and RhlC) which catalyze sequential glycosyl transfer reactions to first form mono-rhamnolipids (via RhIB) and then di-rhamnolipids (via RhIC). RHlA, RHlB, and RHlC are associated with the inner membrane. BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolite Metabolic	diRL(8:0(3-OH)/8:0(3-OH)) dTDP dTDP-4-dehydro-6-deoxy-D-gluco... dTDP-4-dehydro-β-L-rhamnose dTDP-D-glucose dTDP-β-L-rhamnose Glucose 1-phosphate Glucose 6-phosphate HAA(8:0(3-OH)/8:0(3-OH)) Hydrogen Ion Magnesium monoRL(8:0(3-OH)/8:0(3-OH)) NAD NADP NADPH Pyrophosphate Thymidine 5'-triphosphate Water ( show all show less )	3-(3-Hydroxydecanoyloxy)decano... dTDP-4-dehydrorhamnose 3,5-epi... dTDP-4-dehydrorhamnose reducta... dTDP-glucose 4,6-dehydratase Glucose-1-phosphate thymidylyl... Phosphomannomutase/phosphogluc... Rhamnosyltransferase 2 Rhamnosyltransferase chain B ( show all show less )
SMP0127838 View Pathway	rhGAD65 Drug Metabolism Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolite Metabolic		Cystatin-B rhGAD65
SMP0127987 View Pathway	rhIGFBP-3 Drug Metabolism Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolite Metabolic		Cystatin-B rhIGFBP-3
SMP0128310 View Pathway	Rhizopus arrhizus var. arrhizus Drug Metabolism Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolite Metabolic		Cystatin-B Rhizopus arrhizus var. arrhizu...

Showing 227581 - 227590 of 232345 pathways