Browsing Pathways
Showing 41 -
50 of 605359 pathways
PathBank ID | Pathway Name and Description | Pathway Class | Chemical Compounds | Proteins |
---|---|---|---|---|
SMP0122721View Pathway |
chebulagic acid Metabolism 1559277983 1596798296Homo sapiens
|
Metabolite
Signaling
|
|
|
SMP0122484View Pathway |
chebulagic acid Metabolism 1581167212Homo sapiens
|
Metabolite
Signaling
|
|
|
SMP0122497View Pathway |
chebulagic acid Metabolism 1581839290Homo sapiens
|
Metabolite
Signaling
|
|
|
SMP0122514View Pathway |
chebulagic acid Metabolism 1582757459Homo sapiens
|
Metabolite
Signaling
|
||
SMP0122879View Pathway |
chebulagic acid Metabolism 1602639807Homo sapiens
|
Metabolite
Physiological
|
|
|
SMP0122891View Pathway |
chebulagic acid Metabolism 1602980507Homo sapiens
|
Metabolite
Metabolic
|
|
|
SMP0122893View Pathway |
chebulagic acid Metabolism 1602981862Homo sapiens
|
Metabolite
Metabolic
|
|
|
SMP0126782View Pathway |
Dolasetron Serotonin antagonist Action PathwayHomo sapiens
Dolasetron is a selective serotonin 5-HT3 receptor antagonist. In vivo, the drug is rapidly converted into its major active metabolite, hydrodolasetron, which seems to be largely responsible for the drug's pharmacological activity. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.
|
Metabolite
Drug Action
|
||
SMP0126594View Pathway |
Donepezil Acetylcholinesterase Inhibitor Action PathwayHomo sapiens
Donepezil is an acetylcholinesterase inhibitor that is used in the treatment of Alzheimer's Disease and dementia. It is administered orally or transdermally, sometimes in combination with memantine in order to treat moderate to severe dementia. Donepezil selectively inhibits the acetylcholinesterase enzyme, by doing so it is believed to enhance cholinergic transmission to relieve the symptoms of Alzheimer and dementia.
|
Metabolite
Drug Action
|
|
|
SMP0126613View Pathway |
Donepezil Action PathwayHomo sapiens
Donepezil is an acetylcholinesterase inhibitor also known as Adlarity, Aricept and Namzaric, that is used in the treatment of Alzheimer's Disease and dementia. It is administered orally or transdermally, sometimes in combination with memantine in order to treat moderate to severe dementia. Donepezil selectively inhibits the acetylcholinesterase enzyme, by doing so it is believed to enhance cholinergic transmission to relieve the symptoms of Alzheimer's and dementia. Normally acetylcholinesterase breaks down acetylcholine, this inhibited its enhances cholinergic transmission. Donepezil goes through first-pass metabolism by CYP3A4 and CYP2D6 into metabolites which can be further broken down by dealkylation, hydroxylation, oxidation, hydrolysis and glucuronidation.
|
Metabolite
Drug Action
|
|
Showing 41 -
50 of 227586 pathways