Browsing Pathways

In the late 1990s, it was demonstrated that DSR is an obligatory endogenous coagonist of the N-methyl-D-aspartate receptor (NMDAR), functioning in vivo as a specific and potent full agonist at the NMDAR-associated glycine (GLY) modulatory site (GMS). The NMDAR subtype of glutamate (GLU) receptors is widely expressed in the central nervous system (CNS) and has a cardinal role in activity-dependent changes in synaptic strength and connectivity underlying higher brain functions such as memory and learning. NMDAR requires glutamate and glycine or D-serine. D-serine is biosynthesized in glial cells from L-serine which itself is biosynthesized from glucose provided by blood. L-serine can also be transported outside the glial cell and into the post-synaptic neuron where L-serine can be transformed to D-serine through a SR. D-serine gets transported outside the glial cell when glutamate binds to a AMPA. D-serine is also metabolize by a DAAO thus releasing NH3, H2O2 and alpha-Ketoglutaric acid. In schizophrenia, NMDAR shows a glutaminergic hypofunction and increase activity of DAAO. Thus lower concentrations of D-serine are detected in patients with Schizophrenia.

FER participates in many process, its relationship with nodule develop in common bean is yet to be demonstrated

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