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Showing 1 - 10 of 605359 pathways
PathBank ID Pathway Name and Description Pathway Class Chemical Compounds Proteins

SMP0122994

Pw124337 View Pathway

بهمن

Homo sapiens
Metabolite
Physiological

SMP0122307

Pw123617 View Pathway

Ярослав

Arabidopsis thaliana
Metabolite
Signaling

SMP0122863

Pw124202 View Pathway

Егор

Homo sapiens
Metabolite
Metabolic

SMP0145360

Pw147028 View Pathway

γ-Aminobutyric acid Drug Metabolism Pathway

Homo sapiens
Metabolite
Metabolic

SMP0145313

Pw146981 View Pathway

βzole Drug Metabolism Pathway

Homo sapiens
Metabolite
Metabolic

SMP0145372

Pw147040 View Pathway

βhistine Drug Metabolism Pathway

Homo sapiens
Metabolite
Metabolic

SMP0125350

Missing View Pathway

β-oxidación de los ácidos grasos

Homo sapiens
Metabolite
Metabolic

SMP0690018

Missing View Pathway

β-Muricholate secondary bile acid biosynthesis (hdh operon)

Escherichia coli
The biosynthesis of ursocholic acid, a secondary bile acid, is closely associated with the enzymatic activities encoded by the hdh operon in Clostridium absonum. This operon includes two contiguous genes: hdhA, encoding the 7α-hydroxysteroid dehydrogenase (7α-HSDH), and hdhB, coding for the 7β-hydroxysteroid dehydrogenase (7β-HSDH). The process begins with the enzyme 7α-HSDH, which catalyzes the oxidation of cholic acid (CA) at the 7α-hydroxy position, converting it into a 7-keto intermediate. Subsequently, the 7β-HSDH reduces this keto intermediate, but in a stereoselective manner that introduces a 7β-hydroxy group, resulting in the formation of ursocholic acid. The operon appears to be co-regulated, facilitating a coordinated response to bile acids, with promoter and regulatory sequences identified upstream of hdhA and hdhB. The biosynthetic pathway mediated by this operon exemplifies a stereospecific transformation that alters the aromatic configuration of bile acids, enabling bacteria like C. absonum to produce functionally diverse secondary bile acids such as ursocholic acid, which play pivotal roles in host-microbiome interactions and possess potential therapeutic properties.
Metabolite
Metabolic

SMP0650441

Missing View Pathway

β-Muricholate secondary bile acid biosynthesis (hdh operon)

Clostridium sardiniense
The biosynthesis of ursocholic acid, a secondary bile acid, is closely associated with the enzymatic activities encoded by the hdh operon in Clostridium absonum. This operon includes two contiguous genes: hdhA, encoding the 7α-hydroxysteroid dehydrogenase (7α-HSDH), and hdhB, coding for the 7β-hydroxysteroid dehydrogenase (7β-HSDH). The process begins with the enzyme 7α-HSDH, which catalyzes the oxidation of cholic acid (CA) at the 7α-hydroxy position, converting it into a 7-keto intermediate. Subsequently, the 7β-HSDH reduces this keto intermediate, but in a stereoselective manner that introduces a 7β-hydroxy group, resulting in the formation of ursocholic acid. The operon appears to be co-regulated, facilitating a coordinated response to bile acids, with promoter and regulatory sequences identified upstream of hdhA and hdhB. The biosynthetic pathway mediated by this operon exemplifies a stereospecific transformation that alters the aromatic configuration of bile acids, enabling bacteria like C. absonum to produce functionally diverse secondary bile acids such as ursocholic acid, which play pivotal roles in host-microbiome interactions and possess potential therapeutic properties.
Metabolite
Metabolic

SMP0145309

Pw146977 View Pathway

α-Tocopherol Drug Metabolism Pathway

Homo sapiens
Metabolite
Metabolic
Showing 1 - 10 of 524571 pathways