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Pathway Description
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Homo sapiens
Category:
Protein Pathway
Sub-Categories:
Kinase Signaling
Neurological Signaling
Gene Regulatory
Cellular Response
Created: 2013-08-22
Last Updated: 2019-09-12
A member of the G-coupled protein receptor family, the adenosine A2A receptor regulates blood flow to myocardial tissues through the action of vasodilating the coronary arteries, which can potentially lead to hypotension. The adenosine receptor A2a activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response. This occurs through activation of the MAPK/ERK signaling cascade. The A2A receptor has also been demonstrated to play a role in dopamine and glutamate release in the CNS.
References
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine References
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Pubmed: 8670304
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Pubmed: 3095147
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Pubmed: 3093273
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Pubmed: 3131741
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Pubmed: 3127824
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Pubmed: 14702039
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Pubmed: 15372022
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Pubmed: 15489334
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