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Pathway Description
Vasopressin Regulation of Water Homeostasis
Homo sapiens
Category:
Protein Pathway
Sub-Categories:
Protein/Peptide Hormone-Mediated
Kinase Signaling
Disease
Cellular Response
Created: 2013-08-22
Last Updated: 2019-09-12
The vasopressin V2 receptor is found in the kidneys. It serves a role in maintaining corporal water homeostasis. Malfunction of this receptor can lead to Nephrogenic Diabetes Insipidus.
Vasopressin (aka Antidiuretic hormone) activates both follicle-stimulating hormone receptor as well as the V2 receptor G protein complex. From this complex, Guanine nucleotide binding protein G(s) protein reacts with Adenylate Cyclase Type 2, Adeonsine Triphosphate, as well as GTP and magnesium to produce cAMP and Pyrophosphate. cAMP then activates PKA (protein kinase A) which leads to changes in the concentration of water in urine.
References
Vasopressin Regulation of Water Homeostasis References
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Pubmed: 8999963
Krauss, G. Biochemistry of signal transduction and regulation. (3rd ed.) (2003) Weinheim; New York : Wiley-VCH
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van den Ouweland AM, Dreesen JC, Verdijk M, Knoers NV, Monnens LA, Rocchi M, van Oost BA: Mutations in the vasopressin type 2 receptor gene (AVPR2) associated with nephrogenic diabetes insipidus. Nat Genet. 1992 Oct;2(2):99-102. doi: 10.1038/ng1092-99.
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Pubmed: 11714923
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Pubmed: 16710414
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