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Last Updated: 2019-01-29
2,3-Dihydroxybenzoate is synthesized from chorismate via isochorismate and 2,3-dihydroxy-2,3-dihydrobenzoate. Chorismate is a key intermediate and branch point in the biosynthesis of many aromatic compounds. The biosynthesis of 2,3-dihydroxybenzoate from chorismate is catalyzed by three enzymes: EntC, EntB, and EntA. EntC catalyzes the conversion of chorismate to isochorismate. The N-terminal isochorismate lyase domain of EntB hydrolyzes the pyruvate group of isochorismate to produce 2,3-dihydro-2,3-dihydroxybenzoate. The conversion of this latter compound to 2,3-dihydroxybenzoate is catalyzed by the EntA dehydrogenase.
2,3-Dihydroxybenzoate Biosynthesis References
Yamashita S, Buchanan SK: Solute and Ion Transport: Outer Membrane Pores and Receptors. EcoSal Plus. 2010 Sep;4(1). doi: 10.1128/ecosalplus.3.3.1.Pubmed: 26443780
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