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Transcriptional regulator LsrR AI-2 transport protein TqsA AI-2 transport protein TqsA 5'- methylthioadenosine/S- adenosylhomocysteine nucleosidase S- ribosylhomocysteine lyase autoinducer-2 kinase phospho-AI-2 isomerase 3-hydroxy- 2,4- pentadione 5-phosphate thiolase S- ribosylhomocysteine lyase Autoinducer 2 import system permease protein lsrC Autoinducer 2 import system permease protein lsrD Autoinducer-2 ABC transporter - periplasmic binding protein B AI-2 ABC transporter - ATP binding subunit A (2R,4S)-2- methyl- 2,3,3,4- tetrahydroxytetrahydrofuran (2R,4S)-2- methyl- 2,3,3,4- tetrahydroxytetrahydrofuran (2R,4S)-2- methyl- 2,3,3,4- tetrahydroxytetrahydrofuran S- Adenosylhomocysteine H2O Adenine S-ribosyl-L- homocysteine Homocysteine autoinducer 2 (2R,4S)-2- methyl-2,4- dihydroxydihydrofuran- 3-one H2O (2R,4S)-2- methyl- 2,3,3,4- tetrahydroxytetrahydrofuran ATP ADP H+ (4S)-4- hydroxy-2,3- pentanedione 5-phosphate 3-hydroxy- 2,4- pentanedione 5-phosphate CoA Acetyl-CoA Dihydroxyacetone phosphate S- Adenosylmethionine Dimethylglycine H+ βine S-ribosyl-L- homocysteine 4,5- Dihydroxy- 2,3- pentanedione Homocysteine (2R,4S)-2- methyl- 2,3,3,4- tetrahydroxytetrahydrofuran Phosphoribosyl- ATP H2O ADP H+ PPi 3-hydroxy- 2,4- pentanedione 5-phosphate S-Adenosyl-L- Methionine Biosynthesis Transcription of lsrK, lsrR, lsrA, lsrC, lsrD, lsrB, lsrF, lsrG, tam, yneE
lsrR tqsA tqsA mtn luxS lsrK lsrG lsrF luxS lsrC lsrD lsrB lsrA (2R,4S)-2- methyl- 2,3,3,4- tetrahydroxytetrahydrofuran (2R,4S)-2- methyl- 2,3,3,4- tetrahydroxytetrahydrofuran (2R,4S)-2- methyl- 2,3,3,4- tetrahydroxytetrahydrofuran S- Adenosylhomocysteine Water Adenine S-ribosyl-L- homocysteine Homocysteine autoinducer 2 (2R,4S)-2- methyl-2,4- dihydroxydihydrofuran- 3-one Water (2R,4S)-2- methyl- 2,3,3,4- tetrahydroxytetrahydrofuran Adenosine triphosphate Adenosine diphosphate Hydrogen Ion (4S)-4- hydroxy-2,3- pentanedione 5-phosphate 3-hydroxy- 2,4- pentanedione 5-phosphate Coenzyme A Acetyl-CoA Dihydroxyacetone phosphate S- Adenosylmethionine Dimethylglycine Hydrogen Ion βine S-ribosyl-L- homocysteine 4,5- Dihydroxy- 2,3- pentanedione Homocysteine (2R,4S)-2- methyl- 2,3,3,4- tetrahydroxytetrahydrofuran Phosphoribosyl- ATP Water Adenosine diphosphate Hydrogen Ion Pyrophosphate 3-hydroxy- 2,4- pentanedione 5-phosphate S-Adenosyl-L- Methionine Biosynthesis