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Pathway Description
L-Arabinose Degradation I
Escherichia coli
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2015-10-14
Last Updated: 2019-08-14
L-arabinose enters E. coli unphosphorylated via a low-affinity proton-driven transporter (AraE) or a high-affinity ATP-driven system (AraFGH). Following entry, it is converted to L-ribulose-5-phosphate by an isomerase and kinase. L-ribulose-5-phosphate is then converted by an epimerase to the pentose phosphate pathway intermediate, D-xylulose-5-phosphate. D-xylulose-5-phosphate then enters metabolism pathways to become precursor metabolites, reducing power and metabolic energy.
References
L-Arabinose Degradation I References
Fritz G, Megerle JA, Westermayer SA, Brick D, Heermann R, Jung K, Radler JO, Gerland U: Single cell kinetics of phenotypic switching in the arabinose utilization system of E. coli. PLoS One. 2014 Feb 26;9(2):e89532. doi: 10.1371/journal.pone.0089532. eCollection 2014.
Pubmed: 24586851
Schleif R: Regulation of the L-arabinose operon of Escherichia coli. Trends Genet. 2000 Dec;16(12):559-65.
Pubmed: 11102706
Manjasetty BA, Chance MR: Crystal structure of Escherichia coli L-arabinose isomerase (ECAI), the putative target of biological tagatose production. J Mol Biol. 2006 Jul 7;360(2):297-309. doi: 10.1016/j.jmb.2006.04.040. Epub 2006 May 5.
Pubmed: 16756997
Lee N, Gielow W, Martin R, Hamilton E, Fowler A: The organization of the araBAD operon of Escherichia coli. Gene. 1986;47(2-3):231-44. doi: 10.1016/0378-1119(86)90067-3.
Pubmed: 3549454
Yura T, Mori H, Nagai H, Nagata T, Ishihama A, Fujita N, Isono K, Mizobuchi K, Nakata A: Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region. Nucleic Acids Res. 1992 Jul 11;20(13):3305-8. doi: 10.1093/nar/20.13.3305.
Pubmed: 1630901
Lee N, Carbon J: Nucleotide sequence of the 5' end of araBAD operon messenger RNA in Escherichia coli B/r. Proc Natl Acad Sci U S A. 1977 Jan;74(1):49-53. doi: 10.1073/pnas.74.1.49.
Pubmed: 189315
Hirsh J, Schleif R: The araC promoter: transcription, mapping and interaction with the araBAD promoter. Cell. 1977 Jul;11(3):545-50. doi: 10.1016/0092-8674(77)90072-1.
Pubmed: 328165
Sofia HJ, Burland V, Daniels DL, Plunkett G 3rd, Blattner FR: Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes. Nucleic Acids Res. 1994 Jul 11;22(13):2576-86. doi: 10.1093/nar/22.13.2576.
Pubmed: 8041620
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. doi: 10.1038/msb4100049. Epub 2006 Feb 21.
Pubmed: 16738553
Perna NT, Plunkett G 3rd, Burland V, Mau B, Glasner JD, Rose DJ, Mayhew GF, Evans PS, Gregor J, Kirkpatrick HA, Posfai G, Hackett J, Klink S, Boutin A, Shao Y, Miller L, Grotbeck EJ, Davis NW, Lim A, Dimalanta ET, Potamousis KD, Apodaca J, Anantharaman TS, Lin J, Yen G, Schwartz DC, Welch RA, Blattner FR: Genome sequence of enterohaemorrhagic Escherichia coli O157:H7. Nature. 2001 Jan 25;409(6819):529-33. doi: 10.1038/35054089.
Pubmed: 11206551
Hayashi T, Makino K, Ohnishi M, Kurokawa K, Ishii K, Yokoyama K, Han CG, Ohtsubo E, Nakayama K, Murata T, Tanaka M, Tobe T, Iida T, Takami H, Honda T, Sasakawa C, Ogasawara N, Yasunaga T, Kuhara S, Shiba T, Hattori M, Shinagawa H: Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12. DNA Res. 2001 Feb 28;8(1):11-22. doi: 10.1093/dnares/8.1.11.
Pubmed: 11258796
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