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Pathway Description
Xylose Degradation I
Escherichia coli
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2015-10-14
Last Updated: 2019-08-14
Escherichia coli can utilize D-xylose as the sole source of carbon and energy for the cell. A low-affinity proton motive force or a high-affinity ATP-driven (ABC) transport system brings unphosphorylated D-xylose into the cell. Following entry, D-xylose is converted to D-xylulose by an isomerase and then converted to the pentose phosphate pathway intermediate, D-xylulose 5-phosphate via a kinase. D-xylulose 5-phosphate can then enter pathways of metabolism to meet the cells needs.
References
Xylose Degradation I References
Batt CA, Jamieson AC, Vandeyar MA: Identification of essential histidine residues in the active site of Escherichia coli xylose (glucose) isomerase. Proc Natl Acad Sci U S A. 1990 Jan;87(2):618-22.
Pubmed: 2405386
Schellenberg GD, Sarthy A, Larson AE, Backer MP, Crabb JW, Lidstrom M, Hall BD, Furlong CE: Xylose isomerase from Escherichia coli. Characterization of the protein and the structural gene. J Biol Chem. 1984 Jun 10;259(11):6826-32.
Pubmed: 6327696
Lawlis VB, Dennis MS, Chen EY, Smith DH, Henner DJ: Cloning and sequencing of the xylose isomerase and xylulose kinase genes of Escherichia coli. Appl Environ Microbiol. 1984 Jan;47(1):15-21.
Pubmed: 6320721
Briggs KA, Lancashire WE, Hartley BS: Molecular cloning, DNA structure and expression of the Escherichia coli D-xylose isomerase. EMBO J. 1984 Mar;3(3):611-6.
Pubmed: 6325179
Sofia HJ, Burland V, Daniels DL, Plunkett G 3rd, Blattner FR: Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes. Nucleic Acids Res. 1994 Jul 11;22(13):2576-86. doi: 10.1093/nar/22.13.2576.
Pubmed: 8041620
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Davis EO, Henderson PJ: The cloning and DNA sequence of the gene xylE for xylose-proton symport in Escherichia coli K12. J Biol Chem. 1987 Oct 15;262(29):13928-32.
Pubmed: 2820984
Maiden MC, Davis EO, Baldwin SA, Moore DC, Henderson PJ: Mammalian and bacterial sugar transport proteins are homologous. Nature. 1987 Feb 12-18;325(6105):641-3. doi: 10.1038/325641a0.
Pubmed: 3543693
Blattner FR, Burland V, Plunkett G 3rd, Sofia HJ, Daniels DL: Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes. Nucleic Acids Res. 1993 Nov 25;21(23):5408-17. doi: 10.1093/nar/21.23.5408.
Pubmed: 8265357
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