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CHEBI:16015 ChEBI 6022 PubChem-compound P53204 UniProt 937 ChemSpider 1.0 1.0 16597-58-3 CAS 13553 ChemSpider P38169 UniProt 1.0 C00328 KEGG Compound 145043 ChemSpider CHEBI:16027 ChEBI 910 PubChem-compound NAD ATP BioCyc CHEBI:17111 ChEBI H4N Ammonium 18.034374 1.0 559142 ChemSpider 165491 PubChem-compound 5746 ChemSpider 1.0 NICOTINATE_NUCLEOTIDE BioCyc C03722 KEGG Compound 5742 ChemSpider C00455 KEGG Compound CHEBI:16474 ChEBI 952 ChemSpider 7540-64-9 CAS SMILES NC(=O)C1=CC=CN=C1 CHEBI:995 ChEBI CHEBI:18304 ChEBI 5858 ChemSpider C11H12N2O4 N'-Formylkynurenine 236.07971 5735 ChemSpider C02406 KEGG Compound Q06178 UniProt 1010 ChemSpider Saccharomyces cerevisiae 1.0 73-22-3 CAS PPI BioCyc 3''-O-acetyl-ADP-ribose nicotinate beta-D-ribonucleotide C10H12N2O4 3-hydroxy-L-kynurenine 224.07971 3-hydroxy-L-kynurenine 938 PubChem-compound 936 PubChem-compound C11H15NO9P nicotinate beta-D-ribonucleotide 336.04843 C17H23N5O15P2 3''-O-acetyl-ADP-ribose 599.0677 C00119 KEGG Compound 1.0 1.0 Ammonium Hydrogen Ion C5H10N2O3 L-Glutamine 146.06914 1.0 C11H12N2O2 L-Tryptophan 204.08987 CHEBI:16171 ChEBI L-Kynurenine Adenosine triphosphate ReactionCatalysis6417 ACTIVATION ReactionCatalysis6416 ACTIVATION ReactionCatalysis6411 ACTIVATION ReactionCatalysis6410 ACTIVATION ReactionCatalysis6415 ACTIVATION ReactionCatalysis6414 ACTIVATION ReactionCatalysis6413 ACTIVATION ReactionCatalysis6412 ACTIVATION C00009 KEGG Compound 1037 ChemSpider C00008 KEGG Compound C00007 KEGG Compound C00006 KEGG Compound 1.0 CHEBI:18009 ChEBI C00001 KEGG Compound L-ALPHA-ALANINE BioCyc Nicotinic acid mononucleotide C00121 KEGG Compound CHEBI:18361 ChEBI 56-41-7 CAS P47096 UniProt C00005 KEGG Compound SMILES NC(CC(=O)C1=CC=CC=C1NC=O)C(O)=O CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider CHEBI:17154 ChEBI C00002 KEGG Compound Nicotinate D-ribonucleoside 1.0 84 ChemSpider P39683 UniProt P43619 UniProt C21H28N7O14P2 NAD 664.11694 C00011 KEGG Compound C00253 KEGG Compound C01342 KEGG Compound 7339 PubChem-compound HMDB0000902 HMDB 913 ChemSpider 1.0 911 ChemSpider C00013 KEGG Compound QUINOLINATE BioCyc NAD(P) BioCyc 141636 ChemSpider H Hydrogen Ion 1.007825 SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)[N+]4=CC=CC(=C4)C(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 L-Glutamine 56-65-5 CAS L-Tryptophan 53-84-9 CAS C00020 KEGG Compound C00025 KEGG Compound 1.0 1.0 1022-31-7 CAS C00153 KEGG Compound C05841 KEGG Compound Water AMP BioCyc C00041 KEGG Compound SMILES N\C(C(O)=O)=C(\C=C/C=O)/C(O)=O SMILES OC(=O)C1=CN=CC=C1 1094-61-7 CAS HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB0001341 HMDB C04409 KEGG Compound 56-85-9 CAS HMDB0001476 HMDB 886 ChemSpider SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 7062 ChemSpider 1.0 HMDB0000148 HMDB Nicotinamide riboside 2-AMINO-3-CARBOXYMUCONATE_SEMIAL BioCyc P38795 UniProt TRP BioCyc C11H15N2O5 Nicotinamide riboside 255.0981 HMDB0000142 HMDB 53477721 PubChem-compound C11H16NO9P Nicotinic acid mononucleotide 337.05627 121992 PubChem-compound C11H14NO6 Nicotinate D-ribonucleoside 256.08212 7732-18-5 CAS CHEBI:18377 ChEBI NIACINAMIDE BioCyc C00058 KEGG Compound HMDB0006809 HMDB 61-19-8 CAS SMILES NC(=O)C1=CC=C[N+](=C1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 HMDB0001488 HMDB Q04179 UniProt NICOTINAMIDE_RIBOSE BioCyc SMILES OC(=O)C1=CC=CN=C1C(O)=O 56-86-0 CAS FORMATE BioCyc C10H12N2O3 L-Kynurenine 208.0848 C10H16N5O13P3 Adenosine triphosphate 506.99576 613-83-2 CAS C00064 KEGG Compound HMDB0001377 HMDB HMDB0000045 HMDB 1.0 SMILES NC1=C(O)C=CC=C1C(O)=O HMDB0000280 HMDB a [histone]-L-lysine HMDB0000161 HMDB HMDB0000283 HMDB HMDB0001132 HMDB 962 PubChem-compound 388956 ChemSpider C3H7NO2 L-Alanine 89.047676 5800 ChemSpider C00078 KEGG Compound CO2 Carbon dioxide 43.98983 P47125 UniProt Phosphate C00080 KEGG Compound 6450-77-7 CAS SMILES O=O 1.0 HMDB0002111 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O 1341-23-7 CAS 2922-83-0 CAS SMILES OC=O 14265-44-2 CAS P06700 UniProt 58-64-0 CAS C01185 KEGG Compound Q04066 UniProt CHEBI:15927 ChEBI 1.0 644102 PubChem-compound 4932 TAXONOMY 2.7.1.22,2.7.1.173 false 2.7.1.22,2.7.1.173 Adenosine triphosphate + Nicotinamide riboside → Adenosine diphosphate + Hydrogen Ion + Nicotinamide ribotide LEFT_TO_RIGHT Reaction6491 false Adenosine triphosphate + Hydrogen Ion + Nicotinamide ribotide → NAD + Pyrophosphate LEFT_TO_RIGHT 6083 PubChem-compound 6.3.4.21 false 6.3.4.21 Adenosine triphosphate + Nicotinic acid + Phosphoribosyl pyrophosphate + Water → Adenosine diphosphate + Nicotinic acid mononucleotide + Phosphate + Pyrophosphate LEFT_TO_RIGHT 3.5.1.19 false 3.5.1.19 Niacinamide + Water → Ammonium + Nicotinic acid LEFT_TO_RIGHT 64-18-6 CAS [histone]-N6-acetyl-L-lysine Glutamine-dependent NAD(+) synthetase 22833512 PubChem-compound 1.0 Nicotinate-nucleotide pyrophosphorylase [carboxylating] CHEBI:18050 ChEBI H2O Water 18.010565 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 SMILES O[C@H]1[C@@H](O)[C@@H](O[P@](O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O 2.7.7.1,2.7.7.18 false 2.7.7.1,2.7.7.18 Adenosine triphosphate + Hydrogen Ion + Nicotinic acid mononucleotide → Nicotinic acid adenine dinucleotide + Pyrophosphate LEFT_TO_RIGHT 6.3.5.1 false 6.3.5.1 Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water → Adenosine monophosphate + Hydrogen Ion + L-Glutamic acid + NAD + Pyrophosphate LEFT_TO_RIGHT 1.13.11.6 false 1.13.11.6 3-Hydroxyanthranilic acid + Oxygen → 2-Amino-3-carboxymuconic acid semialdehyde + Hydrogen Ion LEFT_TO_RIGHT 3.7.1.3 false 3.7.1.3 3-hydroxy-L-kynurenine + Water → 3-Hydroxyanthranilic acid + Hydrogen Ion + L-Alanine LEFT_TO_RIGHT 1.14.13.9 false 1.14.13.9 Hydrogen Ion + L-Kynurenine + NADPH + Oxygen → 3-hydroxy-L-kynurenine + NADP + Water LEFT_TO_RIGHT 3.5.1.9 false 3.5.1.9 N'-Formylkynurenine + Water → Formic acid + Hydrogen Ion + L-Kynurenine LEFT_TO_RIGHT 1.13.11.52 false 1.13.11.52 L-Tryptophan + Oxygen → N'-Formylkynurenine LEFT_TO_RIGHT NAD BioCyc SMILES OC[C@H]1OC(O)[C@H](O)[C@@H]1O 141580 ChemSpider 977 PubChem-compound 2.4.2.19 false 2.4.2.19 Hydrogen Ion + Phosphoribosyl pyrophosphate + Quinolinic acid → Carbon dioxide + Nicotinic acid mononucleotide + Pyrophosphate LEFT_TO_RIGHT HMDB0059597 HMDB HMDB0041827 HMDB Carbon dioxide L-Alanine P53915 UniProt NIACINE BioCyc HMDB0001179 HMDB Nicotinamidase Nicotinate phosphoribosyltransferase NAD-dependent histone deacetylase SIR2 Uridine nucleosidase Kynurenine formamidase Kynurenine 3-monooxygenase 439924 PubChem-compound Nicotinamide riboside kinase Indoleamine 2,3-dioxygenase Kynureninase Reaction6479 true 2-Amino-3-carboxymuconic acid semialdehyde → Quinolinic acid + Water LEFT_TO_RIGHT 3-hydroxyanthranilate 3,4-dioxygenase 30572 ChemSpider 17215925 ChemSpider 2-Amino-3-carboxymuconic acid semialdehyde 1.0 Nicotinic acid NAD Metabolism SMILES O C03150 KEGG Compound C7H5NO4 Quinolinic acid 167.02185 C11H15N2O8P Nicotinamide ribotide 334.0566 Pyrophosphate C10H14N5O7P Adenosine monophosphate 347.06308 4444266 ChemSpider HMDB0000538 HMDB 5961 PubChem-compound 3-Hydroxyanthranilic acid 1.0 3.2.2.3 false 3.2.2.3 Nicotinamide riboside + Water → D-Ribose + Hydrogen Ion + Niacinamide LEFT_TO_RIGHT CHEBI:15846 ChEBI 3.5.1.- false 3.5.1.- NAD + Water + [histone]-N6-acetyl-L-lysine → a [histone]-L-lysine + 3''-O-acetyl-ADP-ribose + Niacinamide LEFT_TO_RIGHT Reaction6496 false Adenosine triphosphate + Nicotinate D-ribonucleoside → Adenosine diphosphate + Hydrogen Ion + nicotinate beta-D-ribonucleotide LEFT_TO_RIGHT ADP BioCyc CHEBI:15940 ChEBI 1.0 53-59-8 CAS 1038 PubChem-compound 1.0 278 ChemSpider Quinolinic acid Nicotinamide ribotide 274 ChemSpider Adenosine monophosphate 86 PubChem-compound O4P Phosphate 94.95342 HMDB0001406 HMDB NADPH 161234 PubChem-compound HMDB0000684 HMDB SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NADP C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 NADPH BioCyc CHEBI:15763 ChEBI CHEBI:16977 ChEBI 1.0 3-HYDROXY-ANTHRANILATE BioCyc CHEBI:27748 ChEBI HMDB0059646 HMDB CPD-6641 BioCyc 1.0 218 ChemSpider L-Glutamic acid C5H10O5 D-Ribose 150.05283 C5H13O14P3 Phosphoribosyl pyrophosphate 389.9518 SMILES [O-]P([O-])([O-])=O HMDB0000217 HMDB 1.0 Oxygen 124-38-9 CAS Formic acid HMDB0001429 HMDB 548-93-6 CAS SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB 5280673 PubChem-compound SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLN BioCyc GLT BioCyc 53-57-6 CAS Kynurenine formamidase Indoleamine 2,3-dioxygenase Nicotinamide riboside kinase Nicotinate phosphoribosyltransferase 3-hydroxyanthranilate 3,4-dioxygenase Kynureninase Kynurenine 3-monooxygenase C7H7NO3 3-Hydroxyanthranilic acid 153.04259 SMILES O=C=O HMDB0000229 HMDB SMILES C[C@H](N)C(O)=O CHEBI:28938 ChEBI 5950 PubChem-compound 161166 PubChem-compound HMDB0000232 HMDB O7P2 Pyrophosphate 173.91193 HMDB0001200 HMDB C6H5NO2 Nicotinic acid 123.03203 C7H7NO5 2-Amino-3-carboxymuconic acid semialdehyde 185.03242 5957 PubChem-compound CHEBI:16946 ChEBI CHEBI:16828 ChEBI Nicotinamidase P53184 UniProt Uridine nucleosidase D-Ribose Phosphoribosyl pyrophosphate NAD-dependent histone deacetylase SIR2 CPD-560 BioCyc 6066 ChemSpider Adenosine diphosphate 14180 PubChem-compound 90658045 PubChem-compound C10H15N5O10P2 Adenosine diphosphate 427.02942 Nicotinate-nucleotide pyrophosphorylase [carboxylating] 49791998 PubChem-compound Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 HMDB0001330 HMDB Glutamine-dependent NAD(+) synthetase 1.0 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc 6305 PubChem-compound HMDB0000929 HMDB 5682 ChemSpider C6H6N2O Niacinamide 122.04801 1.0 108822 ChemSpider 14000-31-8 CAS a [histone]-L-lysine 5675 ChemSpider SMILES N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O 14798-03-9 CAS 18971002 PubChem-compound NICOTINAMIDE_NUCLEOTIDE BioCyc SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)[N+]1=CC=CC(=C1)C(O)=O SMILES [H]C1(O)O[C@]([H])(COP([O-])(=O)OP([O-])(=O)OC[C@@]2([H])O[C@@]([H])(N3C=NC4=C(N)N=CN=C34)[C@]([H])(O)[C@]2([H])O)[C@@]([H])(OC(C)=O)[C@@]1([H])O SMILES N[C@@H](CC(=O)C1=CC=CC(O)=C1N)C(O)=O CHEBI:15422 ChEBI C00857 KEGG Compound 1.0 1.0 89-00-9 CAS O2 Oxygen 31.98983 CH2O2 Formic acid 46.005478 1.0 Niacinamide C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound Nicotinamide/nicotinic acid mononucleotide adenylyltransferase SMILES [NH4+] SMP0002338 SMPDB CHEBI:16526 ChEBI 5575 ChemSpider 59-67-6 CAS CHEBI:15793 ChEBI CHEBI:16761 ChEBI 7782-44-7 CAS ReactionCatalysis6408 ACTIVATION ReactionCatalysis6407 ACTIVATION ReactionCatalysis6406 ACTIVATION ReactionCatalysis6405 ACTIVATION 1.0 ReactionCatalysis6409 ACTIVATION ReactionCatalysis6404 ACTIVATION ReactionCatalysis6403 ACTIVATION N'-Formylkynurenine 5779 PubChem-compound SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)([O-])=O)[N+]1=CC=CC(C1)C(O)=O C00632 KEGG Compound SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)[N+]1=CC(=CC=C1)C(O)=O 5893 PubChem-compound 1.0 L-KYNURENINE BioCyc Q05979 UniProt CHEBI:30751 ChEBI [histone]-N6-acetyl-L-lysine HMDB0000855 HMDB CHEBI:15377 ChEBI CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1.0 C21H27N6O15P2 Nicotinic acid adenine dinucleotide 665.10095 SMILES N[C@@H](CC(=O)C1=CC=CC=C1N)C(O)=O 1.0 1.0 280 PubChem-compound CHEBI:47013 ChEBI CHEBI:16675 ChEBI Nicotinic acid adenine dinucleotide PW002421 PathWhiz 16741146 PubChem-compound SMILES N[C@@H](CCC(N)=O)C(O)=O 1.0 PRPP BioCyc N-FORMYLKYNURENINE BioCyc 1061 PubChem-compound HMDB0001967 HMDB 1066 PubChem-compound HMDB0000641 HMDB DEAMIDO-NAD BioCyc 98-92-0 CAS 321-02-8 CAS Nicotinate- nucleotide pyrophosphorylase [carboxylating] Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 Glutamine- dependent NAD(+) synthetase 3- hydroxyanthranilate 3,4-dioxygenase Kynureninase Kynurenine 3-monooxygenase Kynurenine formamidase Indoleamine 2,3-dioxygenase Nicotinamide riboside kinase Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 Nicotinate phosphoribosyltransferase Nicotinamidase Uridine nucleosidase NAD-dependent histone deacetylase SIR2 Nicotinamide riboside kinase NAD-dependent histone deacetylase SIR2 2-Amino-3- carboxymuconic acid semialdehyde H 2 O Quinolinic acid H + Phosphoribosyl pyrophosphate PP i CO 2 Nicotinic acid mononucleotide H + ATP Nicotinic acid adenine dinucleotide PP i ATP H 2 O L-Glutamine NAD H + AMP PP i L-Glutamic acid 3- Hydroxyanthranilic acid O 2 H + 3-hydroxy-L- kynurenine H 2 O L-Alanine H + H + NADPH O 2 L-Kynurenine NADP H 2 O N'- Formylkynurenine H 2 O Formic acid H + L-Tryptophan O 2 Nicotinamide riboside ATP Nicotinamide ribotide ADP H + ATP H + PP i NAD H 2 O ATP Phosphoribosyl pyrophosphate Nicotinic acid PP i ADP P i Niacinamide H 2 O Ammonium Nicotinamide riboside H 2 O H + D-Ribose NAD H 2 O 3''-O-acetyl- ADP-ribose ATP Nicotinate D- ribonucleoside ADP H + nicotinate beta-D- ribonucleotide H 2 O 3''-O-acetyl- ADP-ribose Niacinamide [histone]-N6- acetyl-L- lysine a [histone]-L- lysine [histone]-N6- acetyl-L- lysine a [histone]-L- lysine
CHEBI:16015 ChEBI 6022 PubChem-compound P53204 UniProt 937 ChemSpider 1.0 1.0 16597-58-3 CAS 13553 ChemSpider P38169 UniProt 1.0 C00328 KEGG Compound 145043 ChemSpider CHEBI:16027 ChEBI 910 PubChem-compound NAD ATP BioCyc CHEBI:17111 ChEBI H4N Ammonium 18.034374 1.0 559142 ChemSpider 165491 PubChem-compound 5746 ChemSpider 1.0 NICOTINATE_NUCLEOTIDE BioCyc C03722 KEGG Compound 5742 ChemSpider C00455 KEGG Compound CHEBI:16474 ChEBI 952 ChemSpider 7540-64-9 CAS SMILES NC(=O)C1=CC=CN=C1 CHEBI:995 ChEBI CHEBI:18304 ChEBI 5858 ChemSpider C11H12N2O4 N'-Formylkynurenine 236.07971 5735 ChemSpider C02406 KEGG Compound Q06178 UniProt 1010 ChemSpider Saccharomyces cerevisiae 1.0 73-22-3 CAS PPI BioCyc 3''-O-acetyl-ADP-ribose nicotinate beta-D-ribonucleotide C10H12N2O4 3-hydroxy-L-kynurenine 224.07971 3-hydroxy-L-kynurenine 938 PubChem-compound 936 PubChem-compound C11H15NO9P nicotinate beta-D-ribonucleotide 336.04843 C17H23N5O15P2 3''-O-acetyl-ADP-ribose 599.0677 C00119 KEGG Compound 1.0 1.0 Ammonium Hydrogen Ion C5H10N2O3 L-Glutamine 146.06914 1.0 C11H12N2O2 L-Tryptophan 204.08987 CHEBI:16171 ChEBI L-Kynurenine Adenosine triphosphate ReactionCatalysis6417 ACTIVATION ReactionCatalysis6416 ACTIVATION ReactionCatalysis6411 ACTIVATION ReactionCatalysis6410 ACTIVATION ReactionCatalysis6415 ACTIVATION ReactionCatalysis6414 ACTIVATION ReactionCatalysis6413 ACTIVATION ReactionCatalysis6412 ACTIVATION C00009 KEGG Compound 1037 ChemSpider C00008 KEGG Compound C00007 KEGG Compound C00006 KEGG Compound 1.0 CHEBI:18009 ChEBI C00001 KEGG Compound L-ALPHA-ALANINE BioCyc Nicotinic acid mononucleotide C00121 KEGG Compound CHEBI:18361 ChEBI 56-41-7 CAS P47096 UniProt C00005 KEGG Compound SMILES NC(CC(=O)C1=CC=CC=C1NC=O)C(O)=O CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider CHEBI:17154 ChEBI C00002 KEGG Compound Nicotinate D-ribonucleoside 1.0 84 ChemSpider P39683 UniProt P43619 UniProt C21H28N7O14P2 NAD 664.11694 C00011 KEGG Compound C00253 KEGG Compound C01342 KEGG Compound 7339 PubChem-compound HMDB0000902 HMDB 913 ChemSpider 1.0 911 ChemSpider C00013 KEGG Compound QUINOLINATE BioCyc NAD(P) BioCyc 141636 ChemSpider H Hydrogen Ion 1.007825 SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)[N+]4=CC=CC(=C4)C(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 L-Glutamine 56-65-5 CAS L-Tryptophan 53-84-9 CAS C00020 KEGG Compound C00025 KEGG Compound 1.0 1.0 1022-31-7 CAS C00153 KEGG Compound C05841 KEGG Compound Water AMP BioCyc C00041 KEGG Compound SMILES N\C(C(O)=O)=C(\C=C/C=O)/C(O)=O SMILES OC(=O)C1=CN=CC=C1 1094-61-7 CAS HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB0001341 HMDB C04409 KEGG Compound 56-85-9 CAS HMDB0001476 HMDB 886 ChemSpider SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 7062 ChemSpider 1.0 HMDB0000148 HMDB Nicotinamide riboside 2-AMINO-3-CARBOXYMUCONATE_SEMIAL BioCyc P38795 UniProt TRP BioCyc C11H15N2O5 Nicotinamide riboside 255.0981 HMDB0000142 HMDB 53477721 PubChem-compound C11H16NO9P Nicotinic acid mononucleotide 337.05627 121992 PubChem-compound C11H14NO6 Nicotinate D-ribonucleoside 256.08212 7732-18-5 CAS CHEBI:18377 ChEBI NIACINAMIDE BioCyc C00058 KEGG Compound HMDB0006809 HMDB 61-19-8 CAS SMILES NC(=O)C1=CC=C[N+](=C1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 HMDB0001488 HMDB Q04179 UniProt NICOTINAMIDE_RIBOSE BioCyc SMILES OC(=O)C1=CC=CN=C1C(O)=O 56-86-0 CAS FORMATE BioCyc C10H12N2O3 L-Kynurenine 208.0848 C10H16N5O13P3 Adenosine triphosphate 506.99576 613-83-2 CAS C00064 KEGG Compound HMDB0001377 HMDB HMDB0000045 HMDB 1.0 SMILES NC1=C(O)C=CC=C1C(O)=O HMDB0000280 HMDB a [histone]-L-lysine HMDB0000161 HMDB HMDB0000283 HMDB HMDB0001132 HMDB 962 PubChem-compound 388956 ChemSpider C3H7NO2 L-Alanine 89.047676 5800 ChemSpider C00078 KEGG Compound CO2 Carbon dioxide 43.98983 P47125 UniProt Phosphate C00080 KEGG Compound 6450-77-7 CAS SMILES O=O 1.0 HMDB0002111 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O 1341-23-7 CAS 2922-83-0 CAS SMILES OC=O 14265-44-2 CAS P06700 UniProt 58-64-0 CAS C01185 KEGG Compound Q04066 UniProt CHEBI:15927 ChEBI 1.0 644102 PubChem-compound 4932 TAXONOMY 2.7.1.22,2.7.1.173 false 2.7.1.22,2.7.1.173 Adenosine triphosphate + Nicotinamide riboside → Adenosine diphosphate + Hydrogen Ion + Nicotinamide ribotide LEFT_TO_RIGHT Reaction6491 false Adenosine triphosphate + Hydrogen Ion + Nicotinamide ribotide → NAD + Pyrophosphate LEFT_TO_RIGHT 6083 PubChem-compound 6.3.4.21 false 6.3.4.21 Adenosine triphosphate + Nicotinic acid + Phosphoribosyl pyrophosphate + Water → Adenosine diphosphate + Nicotinic acid mononucleotide + Phosphate + Pyrophosphate LEFT_TO_RIGHT 3.5.1.19 false 3.5.1.19 Niacinamide + Water → Ammonium + Nicotinic acid LEFT_TO_RIGHT 64-18-6 CAS [histone]-N6-acetyl-L-lysine Glutamine-dependent NAD(+) synthetase 22833512 PubChem-compound 1.0 Nicotinate-nucleotide pyrophosphorylase [carboxylating] CHEBI:18050 ChEBI H2O Water 18.010565 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 SMILES O[C@H]1[C@@H](O)[C@@H](O[P@](O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O 2.7.7.1,2.7.7.18 false 2.7.7.1,2.7.7.18 Adenosine triphosphate + Hydrogen Ion + Nicotinic acid mononucleotide → Nicotinic acid adenine dinucleotide + Pyrophosphate LEFT_TO_RIGHT 6.3.5.1 false 6.3.5.1 Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water → Adenosine monophosphate + Hydrogen Ion + L-Glutamic acid + NAD + Pyrophosphate LEFT_TO_RIGHT 1.13.11.6 false 1.13.11.6 3-Hydroxyanthranilic acid + Oxygen → 2-Amino-3-carboxymuconic acid semialdehyde + Hydrogen Ion LEFT_TO_RIGHT 3.7.1.3 false 3.7.1.3 3-hydroxy-L-kynurenine + Water → 3-Hydroxyanthranilic acid + Hydrogen Ion + L-Alanine LEFT_TO_RIGHT 1.14.13.9 false 1.14.13.9 Hydrogen Ion + L-Kynurenine + NADPH + Oxygen → 3-hydroxy-L-kynurenine + NADP + Water LEFT_TO_RIGHT 3.5.1.9 false 3.5.1.9 N'-Formylkynurenine + Water → Formic acid + Hydrogen Ion + L-Kynurenine LEFT_TO_RIGHT 1.13.11.52 false 1.13.11.52 L-Tryptophan + Oxygen → N'-Formylkynurenine LEFT_TO_RIGHT NAD BioCyc SMILES OC[C@H]1OC(O)[C@H](O)[C@@H]1O 141580 ChemSpider 977 PubChem-compound 2.4.2.19 false 2.4.2.19 Hydrogen Ion + Phosphoribosyl pyrophosphate + Quinolinic acid → Carbon dioxide + Nicotinic acid mononucleotide + Pyrophosphate LEFT_TO_RIGHT HMDB0059597 HMDB HMDB0041827 HMDB Carbon dioxide L-Alanine P53915 UniProt NIACINE BioCyc HMDB0001179 HMDB Nicotinamidase Nicotinate phosphoribosyltransferase NAD-dependent histone deacetylase SIR2 Uridine nucleosidase Kynurenine formamidase Kynurenine 3-monooxygenase 439924 PubChem-compound Nicotinamide riboside kinase Indoleamine 2,3-dioxygenase Kynureninase Reaction6479 true 2-Amino-3-carboxymuconic acid semialdehyde → Quinolinic acid + Water LEFT_TO_RIGHT 3-hydroxyanthranilate 3,4-dioxygenase 30572 ChemSpider 17215925 ChemSpider 2-Amino-3-carboxymuconic acid semialdehyde 1.0 Nicotinic acid NAD Metabolism SMILES O C03150 KEGG Compound C7H5NO4 Quinolinic acid 167.02185 C11H15N2O8P Nicotinamide ribotide 334.0566 Pyrophosphate C10H14N5O7P Adenosine monophosphate 347.06308 4444266 ChemSpider HMDB0000538 HMDB 5961 PubChem-compound 3-Hydroxyanthranilic acid 1.0 3.2.2.3 false 3.2.2.3 Nicotinamide riboside + Water → D-Ribose + Hydrogen Ion + Niacinamide LEFT_TO_RIGHT CHEBI:15846 ChEBI 3.5.1.- false 3.5.1.- NAD + Water + [histone]-N6-acetyl-L-lysine → a [histone]-L-lysine + 3''-O-acetyl-ADP-ribose + Niacinamide LEFT_TO_RIGHT Reaction6496 false Adenosine triphosphate + Nicotinate D-ribonucleoside → Adenosine diphosphate + Hydrogen Ion + nicotinate beta-D-ribonucleotide LEFT_TO_RIGHT ADP BioCyc CHEBI:15940 ChEBI 1.0 53-59-8 CAS 1038 PubChem-compound 1.0 278 ChemSpider Quinolinic acid Nicotinamide ribotide 274 ChemSpider Adenosine monophosphate 86 PubChem-compound O4P Phosphate 94.95342 HMDB0001406 HMDB NADPH 161234 PubChem-compound HMDB0000684 HMDB SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NADP C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 NADPH BioCyc CHEBI:15763 ChEBI CHEBI:16977 ChEBI 1.0 3-HYDROXY-ANTHRANILATE BioCyc CHEBI:27748 ChEBI HMDB0059646 HMDB CPD-6641 BioCyc 1.0 218 ChemSpider L-Glutamic acid C5H10O5 D-Ribose 150.05283 C5H13O14P3 Phosphoribosyl pyrophosphate 389.9518 SMILES [O-]P([O-])([O-])=O HMDB0000217 HMDB 1.0 Oxygen 124-38-9 CAS Formic acid HMDB0001429 HMDB 548-93-6 CAS SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB 5280673 PubChem-compound SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLN BioCyc GLT BioCyc 53-57-6 CAS Kynurenine formamidase Indoleamine 2,3-dioxygenase Nicotinamide riboside kinase Nicotinate phosphoribosyltransferase 3-hydroxyanthranilate 3,4-dioxygenase Kynureninase Kynurenine 3-monooxygenase C7H7NO3 3-Hydroxyanthranilic acid 153.04259 SMILES O=C=O HMDB0000229 HMDB SMILES C[C@H](N)C(O)=O CHEBI:28938 ChEBI 5950 PubChem-compound 161166 PubChem-compound HMDB0000232 HMDB O7P2 Pyrophosphate 173.91193 HMDB0001200 HMDB C6H5NO2 Nicotinic acid 123.03203 C7H7NO5 2-Amino-3-carboxymuconic acid semialdehyde 185.03242 5957 PubChem-compound CHEBI:16946 ChEBI CHEBI:16828 ChEBI Nicotinamidase P53184 UniProt Uridine nucleosidase D-Ribose Phosphoribosyl pyrophosphate NAD-dependent histone deacetylase SIR2 CPD-560 BioCyc 6066 ChemSpider Adenosine diphosphate 14180 PubChem-compound 90658045 PubChem-compound C10H15N5O10P2 Adenosine diphosphate 427.02942 Nicotinate-nucleotide pyrophosphorylase [carboxylating] 49791998 PubChem-compound Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 HMDB0001330 HMDB Glutamine-dependent NAD(+) synthetase 1.0 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc 6305 PubChem-compound HMDB0000929 HMDB 5682 ChemSpider C6H6N2O Niacinamide 122.04801 1.0 108822 ChemSpider 14000-31-8 CAS a [histone]-L-lysine 5675 ChemSpider SMILES N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O 14798-03-9 CAS 18971002 PubChem-compound NICOTINAMIDE_NUCLEOTIDE BioCyc SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)[N+]1=CC=CC(=C1)C(O)=O SMILES [H]C1(O)O[C@]([H])(COP([O-])(=O)OP([O-])(=O)OC[C@@]2([H])O[C@@]([H])(N3C=NC4=C(N)N=CN=C34)[C@]([H])(O)[C@]2([H])O)[C@@]([H])(OC(C)=O)[C@@]1([H])O SMILES N[C@@H](CC(=O)C1=CC=CC(O)=C1N)C(O)=O CHEBI:15422 ChEBI C00857 KEGG Compound 1.0 1.0 89-00-9 CAS O2 Oxygen 31.98983 CH2O2 Formic acid 46.005478 1.0 Niacinamide C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound Nicotinamide/nicotinic acid mononucleotide adenylyltransferase SMILES [NH4+] SMP0002338 SMPDB CHEBI:16526 ChEBI 5575 ChemSpider 59-67-6 CAS CHEBI:15793 ChEBI CHEBI:16761 ChEBI 7782-44-7 CAS ReactionCatalysis6408 ACTIVATION ReactionCatalysis6407 ACTIVATION ReactionCatalysis6406 ACTIVATION ReactionCatalysis6405 ACTIVATION 1.0 ReactionCatalysis6409 ACTIVATION ReactionCatalysis6404 ACTIVATION ReactionCatalysis6403 ACTIVATION N'-Formylkynurenine 5779 PubChem-compound SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)([O-])=O)[N+]1=CC=CC(C1)C(O)=O C00632 KEGG Compound SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)[N+]1=CC(=CC=C1)C(O)=O 5893 PubChem-compound 1.0 L-KYNURENINE BioCyc Q05979 UniProt CHEBI:30751 ChEBI [histone]-N6-acetyl-L-lysine HMDB0000855 HMDB CHEBI:15377 ChEBI CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1.0 C21H27N6O15P2 Nicotinic acid adenine dinucleotide 665.10095 SMILES N[C@@H](CC(=O)C1=CC=CC=C1N)C(O)=O 1.0 1.0 280 PubChem-compound CHEBI:47013 ChEBI CHEBI:16675 ChEBI Nicotinic acid adenine dinucleotide PW002421 PathWhiz 16741146 PubChem-compound SMILES N[C@@H](CCC(N)=O)C(O)=O 1.0 PRPP BioCyc N-FORMYLKYNURENINE BioCyc 1061 PubChem-compound HMDB0001967 HMDB 1066 PubChem-compound HMDB0000641 HMDB DEAMIDO-NAD BioCyc 98-92-0 CAS 321-02-8 CAS