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Anthranilate synthase component 1 Multifunctional tryptophan biosynthesis protein Anthranilate phosphoribosyltransferase N-(5'- phosphoribosyl)anthranilate isomerase Tryptophan synthase Tryptophan synthase Indoleamine 2,3-dioxygenase Kynurenine formamidase Kynurenine 3-monooxygenase Kynureninase Kynureninase 3- hydroxyanthranilate 3,4-dioxygenase Aromatic/aminoadipate aminotransferase 1 aromatic amino acid aminotransferase II Pyruvate decarboxylase isozyme 1 pyruvate decarboxylase 2 Pyruvate decarboxylase isozyme 3 alcohol dehydrogenase subunit I alcohol dehydrogenase subunit 2 Chorismate L-Glutamine Pyruvic acid L-Glutamic acid H + 2-Aminobenzoic acid Phosphoribosyl pyrophosphate PP i N-(5- phosphoribosyl)- anthranilate 1-(2- carboxyphenylamino)- 1-deoxy-D- ribulose 5-phosphate H + H 2 O CO 2 indoleglycerol phosphate Indole D- Glyceraldehyde 3-phosphate L-Serine H 2 O L-Tryptophan O 2 N'- Formylkynurenine H 2 O Formic acid H + L-Kynurenine H + NADPH O 2 3-hydroxy-L- kynurenine NADP H 2 O H 2 O H + L-Alanine 2-Aminobenzoic acid H 2 O L-Alanine H + 3- Hydroxyanthranilic acid O 2 H + 2-Amino-3- carboxymuconic acid semialdehyde L-Tryptophan Oxoglutaric acid L-Glutamic acid indole-3- pyruvate 2-Oxo-3- phenylpropanoic acid (Mixture oxo and keto) indole-3- pyruvate L-Phenylalanine H + Indoleacetaldehyde CO 2 NADH H + NAD Tryptophol