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Indole Alkaloid Biosynthesis
Last Updated: 2019-01-15
Indole alkaloids are a large class of alkaloids, some of which are used for medical purposes (Wikipedia). The known components of the indole alkaloid biosynthesis pathway in Arabidopsis thaliana are 3 separate reactions, each of which involves reaction with a water molecule. With catalyzation by strictosidine synthase, 3-alpha(s)-strictosidine reacts with water to produce tryptamine and secologanin. With catalyzation by polyneuridine aldehyde esterase, polyneuridine aldehyde reacts with water to form 16-epivellosimine, carbon dioxide, and methanol. And with catalyzation by acetylajmaline esterase, 17-o-acetylnorajmaline reacts with water as well to form norajmaline and acetate.
Indole Alkaloid Biosynthesis References
Vlot AC, Liu PP, Cameron RK, Park SW, Yang Y, Kumar D, Zhou F, Padukkavidana T, Gustafsson C, Pichersky E, Klessig DF: Identification of likely orthologs of tobacco salicylic acid-binding protein 2 and their role in systemic acquired resistance in Arabidopsis thaliana. Plant J. 2008 Nov;56(3):445-56. doi: 10.1111/j.1365-313X.2008.03618.x. Epub 2008 Jul 9.Pubmed: 18643994
Fabbri M, Delp G, Schmidt O, Theopold U: Animal and plant members of a gene family with similarity to alkaloid-synthesizing enzymes. Biochem Biophys Res Commun. 2000 Apr 29;271(1):191-6. doi: 10.1006/bbrc.2000.2598.Pubmed: 10777701
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