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Mitogen- activated protein kinase 7 Protein- tyrosine kinase 2-beta Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Adenylate cyclase type 1 cAMP-dependent protein kinase catalytic subunit alpha Guanine nucleotide- binding protein subunit alpha-11 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 Inositol 1,4,5- trisphosphate receptor type 1 Calmodulin-like protein 6 Calcium/calmodulin- dependent protein kinase type II subunit alpha Protein kinase C beta type Voltage- dependent L-type calcium channel subunit alpha-1D Voltage- dependent L-type calcium channel subunit alpha-1S Voltage- dependent L-type calcium channel subunit alpha-1C Matrix metalloproteinase- 14 72 kDa type IV collagenase Proheparin- binding EGF-like growth factor Epidermal growth factor receptor Growth factor receptor-bound protein 2 Son of sevenless homolog 1 GTPase HRas Cytosolic phospholipase A2 beta Phospholipase D1 Proto-oncogene tyrosine- protein kinase Src Cell division control protein 42 homolog Mitogen- activated protein kinase kinase kinase 1 Progonadoliberin- 1 Gonadotropin- releasing hormone receptor Mitogen- activated protein kinase kinase kinase 2 Lutropin subunit beta Glycoprotein hormones alpha chain Follitropin subunit beta Cyclic AMP-dependent transcription factor ATF-4 Dual specificity mitogen- activated protein kinase kinase 3 Mitogen- activated protein kinase 14 RAF proto-oncogene serine/threonine- protein kinase Dual specificity mitogen- activated protein kinase kinase 1 Mitogen- activated protein kinase 1 Early growth response protein 1 ETS domain- containing protein Elk-1 Dual specificity mitogen- activated protein kinase kinase 7 Mitogen- activated protein kinase 8 Transcription factor AP-1 cAMP Ca+ Ca+ Arachidonic acid Ca+ Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Protein kinase C alpha type IP3 DG Phosphatidic Acid Neuroactive ligand-receptor interaction Gonadotropins gene expression & secretion Indirect link or Unknown reaction cytokine-cytokine receptor interactions Indirect link or Unknown reaction Extracellular Space Cytoplasm of Pituitary gonadotrope cell Nucleus Indirect link or Unknown reaction cAMP Signaling Pathway Calcium Signaling Pathway Erk1/Erk2 Mapk Signaling Pathway
Nucleus MAPK7 PTK2B GNAS ADCY1 PRKACA GNA11 PLCB1 ITPR1 CALML6 CAMK2A PRKCB CACNA1D CACNA1S CACNA1C MMP14 MMP2 HBEGF EGFR GRB2 SOS1 HRAS PLA2G4B PLD1 SRC CDC42 MAP3K1 GNRH1 GNRHR MAP3K2 LHB Unknown Unknown ATF4 MAP2K3 MAPK14 RAF1 MAP2K1 MAPK1 EGR1 ELK1 MAP2K7 MAPK8 JUN cAMP Calcium Calcium Arachidonic acid Calcium Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate PRKCA IP3 DG Phosphatidic Acid
MAPK7 PTK2B GNAS ADCY1 PRKACA GNA11 PLCB1 ITPR1 CALML6 CAMK2A PRKCB CACNA1D CACNA1S CACNA1C MMP14 MMP2 HBEGF EGFR GRB2 SOS1 HRAS PLA2G4B PLD1 SRC CDC42 MAP3K1 GNRH1 GNRHR MAP3K2 LHB ATF4 MAP2K3 MAPK14 RAF1 MAP2K1 MAPK1 EGR1 ELK1 MAP2K7 MAPK8 JUN cAMP Ca+ Ca+ 20:4 Ca+ Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi PRKCA IP3 DG PA Neuroactive ligand-receptor interaction Gonadotropins gene expression & secretion Indirect link or Unknown reaction cytokine-cytokine receptor interactions Indirect link or Unknown reaction Extracellular Space Cytoplasm of Pituitary gonadotrope cell Nucleus Indirect link or Unknown reaction cAMP Signaling Pathway Calcium Signaling Pathway Erk1/Erk2 Mapk Signaling Pathway