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P2Y purinoceptor 12 Gαi Adenylate Cyclase Plasma membrane Ca-ADPase Cangrelor ADP cAMP Ca+ Ca+ Magnesium cAMP Cangrelor has high affinity for the P2Y12 receptor to which it binds reversibly, preventing binding of ADP. Gi protein no longer inhibits adenylate cyclase, leading to a buildup of cAMP activating calcium efflux pump and prevents platelet activation Normally, ADP binds to P2Y12, activating the coupled Gi protein, inhibiting adenylate cyclase and leading to a shortage of cAMP. Calcium efflux is inactivated by lack of cAMP, inducing platelet activation and aggregation. Platelet Extracellular Space Affected Organs Symptom Relief Blood Clot Blood Vessel or Cell Damage Cangrelor is administered intravenously and travels through the bloodstream Blood Vessel
Melanosome Chloroplast Chloroplast P2RY12 GNAI1 ADCY10 Unknown Cangrelor Adenosine diphosphate cAMP Calcium Calcium
P2RY12 GNAI1 ADCY10 Cangrel ADP cAMP Ca+ Ca+ Mg2+ cAMP Cangrelor has high affinity for the P2Y12 receptor to which it binds reversibly, preventing binding of ADP. Gi protein no longer inhibits adenylate cyclase, leading to a buildup of cAMP activating calcium efflux pump and prevents platelet activation Normally, ADP binds to P2Y12, activating the coupled Gi protein, inhibiting adenylate cyclase and leading to a shortage of cAMP. Calcium efflux is inactivated by lack of cAMP, inducing platelet activation and aggregation. Platelet Extracellular Space Affected Organs Symptom Relief Blood Clot Blood Vessel or Cell Damage Cangrelor is administered intravenously and travels through the bloodstream Blood Vessel
Melanosome Chloroplast Chloroplast P2RY12 GNAI1 ADCY10 Cangrel ADP cAMP Ca2+ Ca2+