Browsing Pathways
Showing 51 -
60 of 605359 pathways
PathBank ID | Pathway Name and Description | Pathway Class | Chemical Compounds | Proteins |
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SMP0126472View Pathway |
Ziprasidone Dopamine Antagonist Action PathwayHomo sapiens
Ziprasidone is an atypical antipsychotic used to treat schizophrenia, bipolar mania, and acute agitation in schizophrenic patients. It also indicated improvement on the manic syndrome subscale that measures symptoms of mania such as mood, insomnia, excessive energy and activity, and overall behavior and ideation. Ziprasidone is also used as off-labeled for monotherapy in acute hypomania, monotherapy as maintenance treatment for adult patients with bipolar I disorder, hyperactivity treatment, and for the treatment of delirium in the ICU. Ziprasidone presents in both oral capsule and intramuscular injection formulations. Ziprasidone is an atypical antipsychotic that has a binding affinity for dopaminergic (DA), serotonergic (5HT), adrenergic (a1), and histaminergic (HA) receptors. Regarding treatment for schizophrenia, antagonism of the dopamine (D2) receptor in the mesolimbic pathway has proven efficacious in diminishing positive symptoms, whereas the antagonism of the 5HT2A receptor in the mesocortical pathway has demonstrated reduction of negative symptoms of psychosis. Its efficacy and mechanism of action for treating bipolar disorder are unknown. The antagonization of both histaminergic and adrenergic (a1) receptors can induce somnolence and orthostatic hypotension.
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SMP0145180View Pathway |
Zinc sulfate, unspecified form Drug Metabolism Action PathwayHomo sapiens
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SMP0144421View Pathway |
Zinc sulfate Drug Metabolism Action PathwayHomo sapiens
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SMP0145272View Pathway |
Zinc phenolsulfonate Drug Metabolism Action PathwayHomo sapiens
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SMP0130543View Pathway |
Zinc phenolsulfonate Drug MetabolismHomo sapiens
Zinc phenolsulfonate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Zinc phenolsulfonate passes through the liver and is then excreted from the body mainly through the kidney.
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SMP0144420View Pathway |
Zinc oxide Drug Metabolism Action PathwayHomo sapiens
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SMP0144650View Pathway |
Zinc gluconate Drug Metabolism Action PathwayHomo sapiens
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SMP0130547View Pathway |
Zinc gluconate Drug MetabolismHomo sapiens
Zinc gluconate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Zinc gluconate passes through the liver and is then excreted from the body mainly through the kidney.
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SMP0143794View Pathway |
Zinc Drug Metabolism Action PathwayHomo sapiens
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SMP0145122View Pathway |
Zinc dibutyldithiocarbamate Drug Metabolism Action PathwayHomo sapiens
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Showing 51 -
60 of 234577 pathways